Arih1 ariadne RBR E3 ubiquitin protein ligase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Arih1provided by MGI
Official Full Name: ariadne RBR E3 ubiquitin protein ligase 1provided by MGI
Primary source: MGI:MGI:1344363
See related: Ensembl:ENSMUSG00000025234 AllianceGenome:MGI:1344363
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ari; Ari1; Hari; Hhari; Uip77; Ubch7bp
Summary: Predicted to enable enzyme binding activity; ubiquitin protein ligase activity; and zinc ion binding activity. Acts upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be located in Lewy body and nuclear body. Predicted to be part of cullin-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in hippocampus. Orthologous to human ARIH1 (ariadne RBR E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 9.4), testis adult (RPKM 8.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 B; 9 32.01 cM

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (59295837..59395469, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (59388554..59488186, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS.
Title: The E3 ubiquitin ligase ARIH1 promotes antiviral immunity and autoimmunity by inducing mono-ISGylation and oligomerization of cGAS.
2,3,7,8-tetrachlorodibenzo-p-dioxin promotes the aryl hydrocarbon receptor binding to Ubch7 gene promoter as well as its transactivation, resulting in an induction of UbcH7 levels in the olfactory bulb, ventral midbrain, hippocampus, striatum, cerebral cortex, brain stem, and medulla oblongata.
Title: TCDD induces UbcH7 expression and synphilin-1 protein degradation in the mouse ventral midbrain.
DNA damage induces an increase in ARIH1 protein levels and association of ARIH1 with 4EHP. In turn, this causes 4EHP recruitment to the mRNA cap, where it is known to compete with eIF4E.
Title: The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.
Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.
Title: Ndfip1 regulates itch ligase activity and airway inflammation via UbcH7.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Gene trapped (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AU021774 (e-PCR)
- UniSTS:208384

D9Mit102 (e-PCR), detects polymorphism
- UniSTS:131651

NoName (e-PCR)
- UniSTS:548445

NoName (e-PCR)
- UniSTS:236149

NoName (e-PCR)
- UniSTS:236158

D9Ertd815e (e-PCR), detects polymorphism
- UniSTS:167631

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ubiquitin conjugating enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin conjugating enzyme binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin conjugating enzyme binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISS Inferred from Sequence or Structural Similarity more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in Cajal body	IEA Inferred from Electronic Annotation more info
part_of Cul2-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul2-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Cul3-RING ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul3-RING ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Cul4A-RING E3 ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of Cul4A-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
located_in Lewy body	ISO Inferred from Sequence Orthology more info
located_in Lewy body	ISS Inferred from Sequence or Structural Similarity more info
part_of SCF ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of SCF ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase ARIH1

Names: ARI-1; RING-type E3 ubiquitin transferase ARIH1; UbcH7-binding protein; UbcM4-interacting protein 77; ariadne 1; ariadne ubiquitin-conjugating enzyme E2 binding protein homolog 1; protein ariadne-1 homolog; ubiquitin-conjugating enzyme E2-binding protein 1

NP_064311.2

EC 2.3.2.31

XP_006511203.1

EC 2.3.2.31

XP_006511204.1

EC 2.3.2.31

XP_011241041.1

EC 2.3.2.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019927.2 → NP_064311.2 E3 ubiquitin-protein ligase ARIH1

See identical proteins and their annotated locations for NP_064311.2

Status: VALIDATED

Source sequence(s)

AJ130977, AK032640, AK047617, AW125831, CA328699, CJ176800, CK633971, CV555932

Consensus CDS

CCDS52817.1

UniProtKB/Swiss-Prot

E9Q1X3, Q6PF92, Q8CFJ4, Q9Z1K5

UniProtKB/TrEMBL

H9KV21

Related

ENSMUSP00000126531.2, ENSMUST00000171975.8

Conserved Domains (3) summary

smart00647
Location:255 → 315

IBR; In Between Ring fingers

cd16626
Location:183 → 240

RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins

pfam01485
Location:337 → 377

IBR; IBR domain, a half RING-finger domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000075.7 Reference GRCm39 C57BL/6J

Range

59295837..59395469 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006511140.4 → XP_006511203.1 E3 ubiquitin-protein ligase ARIH1 isoform X1

UniProtKB/TrEMBL

H9KV21

Conserved Domains (3) summary

smart00647
Location:196 → 256

IBR; In Between Ring fingers

cd16626
Location:124 → 181

RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins

pfam01485
Location:278 → 318

IBR; IBR domain, a half RING-finger domain
XM_006511141.3 → XP_006511204.1 E3 ubiquitin-protein ligase ARIH1 isoform X3

UniProtKB/TrEMBL

H9KV21

Conserved Domains (3) summary

smart00647
Location:165 → 225

IBR; In Between Ring fingers

cd16626
Location:93 → 150

RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins

pfam01485
Location:247 → 287

IBR; IBR domain, a half RING-finger domain
XM_011242739.3 → XP_011241041.1 E3 ubiquitin-protein ligase ARIH1 isoform X2

UniProtKB/TrEMBL

H9KV21

Conserved Domains (3) summary

smart00647
Location:173 → 233

IBR; In Between Ring fingers

cd16626
Location:101 → 158

RING-HC_RBR_HHARI; RING finger, HC subclass, found in human homolog of Drosophila ariadne (HHARI) and similar proteins

pfam01485
Location:255 → 295

IBR; IBR domain, a half RING-finger domain