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    Chmp3 charged multivesicular body protein 3 [ Mus musculus (house mouse) ]

    Gene ID: 66700, updated on 9-Dec-2024

    Summary

    Official Symbol
    Chmp3provided by MGI
    Official Full Name
    charged multivesicular body protein 3provided by MGI
    Primary source
    MGI:MGI:1913950
    See related
    Ensembl:ENSMUSG00000053119 AllianceGenome:MGI:1913950
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    25.1; NEDF; Vps24; CGI-49; D6Ertd286e; 4921505F14Rik; 9130011K15Rik
    Summary
    Predicted to enable several functions, including identical protein binding activity; phospholipid binding activity; and ubiquitin-specific protease binding activity. Predicted to be involved in several processes, including midbody abscission; regulation of cell cycle process; and vacuolar transport. Predicted to be located in several cellular components, including bounding membrane of organelle; early endosome; and kinetochore microtubule. Predicted to be part of ESCRT III complex and nuclear pore. Predicted to be active in multivesicular body. Is expressed in brain; male reproductive gland or organ; metanephros; and neural retinal epithelium. Orthologous to several human genes including CHMP3 (charged multivesicular body protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bladder adult (RPKM 24.4), cerebellum adult (RPKM 16.8) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Chmp3 in Genome Data Viewer
    Location:
    6 C1; 6 32.17 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (71520820..71559593)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (71543831..71582609)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30582 Neighboring gene STARR-positive B cell enhancer ABC_E10384 Neighboring gene ring finger protein 103 Neighboring gene STARR-positive B cell enhancer ABC_E8110 Neighboring gene lysine (K)-specific demethylase 3A Neighboring gene STARR-seq mESC enhancer starr_16264 Neighboring gene STARR-seq mESC enhancer starr_16265 Neighboring gene STARR-positive B cell enhancer ABC_E3659 Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:71583085-71583314 Neighboring gene STARR-positive B cell enhancer ABC_E9095 Neighboring gene peptidylprolyl isomerase A pseudogene 6_731.1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Items 1 - 25 of 30
    Process Evidence Code Pubs
    involved_in autophagosome maturation  
    involved_in autophagy  
    involved_in endosome to lysosome transport  
    involved_in endosome transport via multivesicular body sorting pathway  
    involved_in late endosome to lysosome transport  
    involved_in late endosome to vacuole transport  
    involved_in membrane fission PubMed 
    involved_in midbody abscission  
    involved_in mitotic metaphase chromosome alignment  
    involved_in multivesicular body assembly PubMed 
    involved_in multivesicular body sorting pathway  
    involved_in multivesicular body-lysosome fusion PubMed 
    involved_in nuclear membrane reassembly  
    involved_in nucleus organization  
    involved_in plasma membrane repair  
    involved_in positive regulation of cytokinesis  
    involved_in positive regulation of cytokinesis  
    involved_in protein polymerization  
    involved_in protein transport  
    involved_in protein transport  
    involved_in regulation of centrosome duplication  
    involved_in regulation of early endosome to late endosome transport  
    involved_in regulation of endosome size  
    involved_in regulation of endosome size  
    involved_in regulation of mitotic spindle assembly  
    involved_in suppression of viral release by host  
    involved_in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway  
    involved_in vesicle fusion with vacuole PubMed 
    involved_in viral budding from plasma membrane  
    involved_in viral budding via host ESCRT complex  
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    part_of ESCRT III complex  
    part_of ESCRT III complex  
    part_of ESCRT III complex  
    located_in amphisome membrane  
    located_in autophagosome membrane  
    located_in cytoplasmic vesicle  
    located_in cytosol  
    located_in early endosome  
    located_in early endosome  
    located_in kinetochore  
    located_in kinetochore microtubule  
    located_in late endosome  
    located_in lysosomal membrane  
    located_in midbody  
    is_active_in multivesicular body  
    located_in multivesicular body membrane  
    part_of nuclear pore  
    located_in plasma membrane  

    General protein information

    Preferred Names
    charged multivesicular body protein 3
    Names
    chromatin-modifying protein 3
    neuroendocrine differentiation factor
    vacuolar protein sorting-associated protein 24

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355674.1NP_001342603.1  charged multivesicular body protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC118686
      Conserved Domains (1) summary
      pfam03357
      Location:1161
      Snf7
    2. NM_001355675.1NP_001342604.1  charged multivesicular body protein 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC118686
      Conserved Domains (1) summary
      pfam03357
      Location:1161
      Snf7
    3. NM_001361405.1NP_001348334.1  charged multivesicular body protein 3 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC118686, AK014818, BY264596
      Consensus CDS
      CCDS20232.1
      UniProtKB/Swiss-Prot
      Q9CQ10, Q9D2Z2, Q9D7A5
      Related
      ENSMUSP00000068410.3, ENSMUST00000065364.5
      Conserved Domains (1) summary
      pfam03357
      Location:18187
      Snf7
    4. NM_025783.4NP_080059.2  charged multivesicular body protein 3 isoform 1

      See identical proteins and their annotated locations for NP_080059.2

      Status: VALIDATED

      Source sequence(s)
      AI848675, AK083562, BY264596
      Consensus CDS
      CCDS20232.1
      UniProtKB/Swiss-Prot
      Q9CQ10, Q9D2Z2, Q9D7A5
      Related
      ENSMUSP00000109815.4, ENSMUST00000059462.12
      Conserved Domains (1) summary
      pfam03357
      Location:18187
      Snf7

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      71520820..71559593
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506481.5XP_006506544.1  charged multivesicular body protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006506544.1

      Conserved Domains (1) summary
      cl21588
      Location:1121
      Snf7
    2. XM_030255546.2XP_030111406.1  charged multivesicular body protein 3 isoform X1

      Conserved Domains (1) summary
      cl21588
      Location:1121
      Snf7
    3. XM_036152263.1XP_036008156.1  charged multivesicular body protein 3 isoform X1

      Conserved Domains (1) summary
      cl21588
      Location:1121
      Snf7
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