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    Stac3 SH3 and cysteine rich domain 3 [ Mus musculus (house mouse) ]

    Gene ID: 237611, updated on 9-Dec-2024

    Summary

    Official Symbol
    Stac3provided by MGI
    Official Full Name
    SH3 and cysteine rich domain 3provided by MGI
    Primary source
    MGI:MGI:3606571
    See related
    Ensembl:ENSMUSG00000040287 AllianceGenome:MGI:3606571
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830125E18
    Summary
    Predicted to enable identical protein binding activity. Involved in positive regulation of protein localization to plasma membrane and positive regulation of voltage-gated calcium channel activity. Acts upstream of or within skeletal muscle fiber development. Located in cytoplasmic side of plasma membrane and cytosol. Part of voltage-gated calcium channel complex. Is expressed in limb musculature; somite; and tongue. Human ortholog(s) of this gene implicated in Native American myopathy. Orthologous to human STAC3 (SH3 and cysteine rich domain 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in mammary gland adult (RPKM 5.1), limb E14.5 (RPKM 4.7) and 11 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Stac3 in Genome Data Viewer
    Location:
    10 D3; 10 74.5 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127337505..127344692)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127501617..127508823)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene inhibin beta-C Neighboring gene R3H domain containing 2 Neighboring gene predicted gene, 23819 Neighboring gene STARR-positive B cell enhancer mm9_chr10:126945421-126945721 Neighboring gene STARR-positive B cell enhancer ABC_E10656 Neighboring gene STARR-positive B cell enhancer ABC_E2342 Neighboring gene Ndufa4, mitochondrial complex associated like 2 Neighboring gene STARR-positive B cell enhancer ABC_E1132 Neighboring gene serine hydroxymethyltransferase 2 (mitochondrial) Neighboring gene neurexophilin 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1) 

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding  
    enables identical protein binding  
    enables metal ion binding  
    Component Evidence Code Pubs
    located_in T-tubule  
    located_in cytoplasmic side of plasma membrane PubMed 
    located_in cytosol PubMed 
    located_in cytosol  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in synapse  
    part_of voltage-gated calcium channel complex PubMed 

    General protein information

    Preferred Names
    SH3 and cysteine-rich domain-containing protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001359751.1NP_001346680.1  SH3 and cysteine-rich domain-containing protein 3

      Status: VALIDATED

      Source sequence(s)
      AC167719, BC067208
      Consensus CDS
      CCDS24242.1
      UniProtKB/Swiss-Prot
      Q8BZ71
      Related
      ENSMUSP00000125124.2, ENSMUST00000160019.8
      Conserved Domains (4) summary
      cd11834
      Location:306356
      SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
      cd11986
      Location:247299
      SH3_Stac3_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 3 (Stac3)
      pfam00130
      Location:89134
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam16664
      Location:146187
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
    2. NM_177707.4NP_808375.1  SH3 and cysteine-rich domain-containing protein 3

      See identical proteins and their annotated locations for NP_808375.1

      Status: VALIDATED

      Source sequence(s)
      AK036516, BC067208
      Consensus CDS
      CCDS24242.1
      UniProtKB/Swiss-Prot
      Q8BZ71
      Related
      ENSMUSP00000048148.3, ENSMUST00000035839.3
      Conserved Domains (4) summary
      cd11834
      Location:306356
      SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
      cd11986
      Location:247299
      SH3_Stac3_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 3 (Stac3)
      pfam00130
      Location:89134
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam16664
      Location:146187
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      127337505..127344692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513640.3XP_006513703.1  SH3 and cysteine-rich domain-containing protein 3 isoform X1

      See identical proteins and their annotated locations for XP_006513703.1

      UniProtKB/Swiss-Prot
      Q8BZ71
      Conserved Domains (4) summary
      cd11834
      Location:306356
      SH3_Stac_2; Second C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing proteins 1 and 3
      cd11986
      Location:247299
      SH3_Stac3_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing protein 3 (Stac3)
      pfam00130
      Location:89134
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam16664
      Location:146187
      STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2
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