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    Tmem229b transmembrane protein 229B [ Mus musculus (house mouse) ]

    Gene ID: 268567, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tmem229bprovided by MGI
    Official Full Name
    transmembrane protein 229Bprovided by MGI
    Primary source
    MGI:MGI:2444389
    See related
    Ensembl:ENSMUSG00000046157 AllianceGenome:MGI:2444389
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9830138K24; 6330442E10Rik
    Summary
    Acts upstream of or within macrophage activation and response to bacterium. Predicted to be located in membrane. Is expressed in cerebral cortex intermediate zone and cortical plate. Orthologous to human TMEM229B (transmembrane protein 229B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in thymus adult (RPKM 17.0), CNS E18 (RPKM 15.4) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem229b in Genome Data Viewer
    Location:
    12 C3; 12 35.51 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (79008569..79054333, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (78961795..79007559, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene pleckstrin 2 Neighboring gene STARR-seq mESC enhancer starr_32580 Neighboring gene predicted gene, 46359 Neighboring gene STARR-seq mESC enhancer starr_32581 Neighboring gene predicted gene, 46360 Neighboring gene STARR-seq mESC enhancer starr_32582 Neighboring gene STARR-seq mESC enhancer starr_32583 Neighboring gene STARR-seq mESC enhancer starr_32585 Neighboring gene STARR-seq mESC enhancer starr_32589 Neighboring gene pleckstrin homology domain containing, family H (with MyTH4 domain) member 1 Neighboring gene predicted gene, 53729 Neighboring gene RIKEN cDNA 9230116L04 gene Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MiR-505 promotes M2 polarization in choroidal neovascularization model mice by targeting transmembrane protein 229B. Zhao S, et al. Scand J Immunol, 2019 Dec. PMID 31544253
    2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Ko MS, et al. Development, 2000 Apr. PMID 10725249
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Our data have uncovered the critical contribution of miR-505 in AMD, which is predominantly mediated by downregulation of TMEM229B.
      Title: MiR-505 promotes M2 polarization in choroidal neovascularization model mice by targeting transmembrane protein 229B.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within macrophage activation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 229B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001170401.2 → NP_001163872.1  transmembrane protein 229B

      See identical proteins and their annotated locations for NP_001163872.1

      Status: VALIDATED

      Source sequence(s)
      AC165249, BC057677
      Consensus CDS
      CCDS26005.1
      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Related
      ENSMUSP00000070637.8, ENSMUST00000070174.14
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    2. NM_001364891.1 → NP_001351820.1  transmembrane protein 229B

      Status: VALIDATED

      Source sequence(s)
      AC165249
      Consensus CDS
      CCDS26005.1
      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    3. NM_001364892.1 → NP_001351821.1  transmembrane protein 229B

      Status: VALIDATED

      Source sequence(s)
      AC165249
      Consensus CDS
      CCDS26005.1
      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Related
      ENSMUSP00000134376.2, ENSMUST00000174072.8
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    4. NM_178745.5 → NP_848860.1  transmembrane protein 229B

      See identical proteins and their annotated locations for NP_848860.1

      Status: VALIDATED

      Source sequence(s)
      BC057677, BC066067
      Consensus CDS
      CCDS26005.1
      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Related
      ENSMUSP00000053835.7, ENSMUST00000056660.13
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      79008569..79054333 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515914.2 → XP_006515977.1  transmembrane protein 229B isoform X1

      See identical proteins and their annotated locations for XP_006515977.1

      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    2. XM_030246737.1 → XP_030102597.1  transmembrane protein 229B isoform X1

      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Related
      ENSMUSP00000134348.2, ENSMUST00000174697.2
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    3. XM_006515913.3 → XP_006515976.1  transmembrane protein 229B isoform X1

      See identical proteins and their annotated locations for XP_006515976.1

      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    4. XM_006515909.3 → XP_006515972.1  transmembrane protein 229B isoform X1

      See identical proteins and their annotated locations for XP_006515972.1

      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    5. XM_006515915.5 → XP_006515978.1  transmembrane protein 229B isoform X1

      See identical proteins and their annotated locations for XP_006515978.1

      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    6. XM_030246736.2 → XP_030102596.1  transmembrane protein 229B isoform X1

      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    7. XM_036157432.1 → XP_036013325.1  transmembrane protein 229B isoform X1

      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    8. XM_036157433.1 → XP_036013326.1  transmembrane protein 229B isoform X1

      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    9. XM_036157434.1 → XP_036013327.1  transmembrane protein 229B isoform X1

      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    10. XM_030246734.1 → XP_030102594.1  transmembrane protein 229B isoform X1

      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV

    11. XM_030246735.2 → XP_030102595.1  transmembrane protein 229B isoform X1

      UniProtKB/Swiss-Prot
      Q3UDU2, Q6AXE5, Q8BFQ2, Q8CCD3
      Conserved Domains (1) summary
      cl26964
      Location:50 → 135
      ABC_trans_CmpB; Putative ABC-transporter type IV
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BFQ2.1 GenPept UniProtKB/Swiss-Prot:Q8BFQ2

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