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    Drd1 dopamine receptor D1 [ Mus musculus (house mouse) ]

    Gene ID: 13488, updated on 17-Dec-2024

    Summary

    Official Symbol
    Drd1provided by MGI
    Official Full Name
    dopamine receptor D1provided by MGI
    Primary source
    MGI:MGI:99578
    See related
    Ensembl:ENSMUSG00000021478 AllianceGenome:MGI:99578
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Drd-1; Drd1a; Gpcr15; C030036C15Rik
    Summary
    Enables G protein-coupled receptor activity and dopamine neurotransmitter receptor activity, coupled via Gs. Involved in adenylate cyclase-activating dopamine receptor signaling pathway; modification of postsynaptic structure; and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within several processes, including central nervous system development; learning or memory; and modulation of chemical synaptic transmission. Located in several cellular components, including dendritic spine; endoplasmic reticulum; and nucleus. Is active in GABA-ergic synapse; glutamatergic synapse; and synaptic membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and sensory organ. Used to study Huntington's disease. Human ortholog(s) of this gene implicated in hypertension and kidney failure. Orthologous to human DRD1 (dopamine receptor D1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in cortex adult (RPKM 2.4), CNS E18 (RPKM 1.8) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Drd1 in Genome Data Viewer
    Location:
    13 B1; 13 28.4 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (54205202..54209677, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (54051183..54055658, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA E130119H09 gene Neighboring gene predicted gene, 34557 Neighboring gene sideroflexin 1 Neighboring gene ribosomal protein, large, P0 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding  
    enables D3 dopamine receptor binding  
    enables G protein-coupled receptor activity  
    enables G protein-coupled receptor activity PubMed 
    enables G protein-coupled receptor activity  
    enables G-protein alpha-subunit binding  
    enables G-protein alpha-subunit binding  
    enables angiotensin receptor binding  
    enables arrestin family protein binding  
    enables arrestin family protein binding  
    enables dopamine binding  
    enables dopamine binding  
    enables dopamine neurotransmitter receptor activity PubMed 
    enables dopamine neurotransmitter receptor activity  
    enables dopamine neurotransmitter receptor activity, coupled via Gs  
    enables dopamine neurotransmitter receptor activity, coupled via Gs PubMed 
    enables dopamine neurotransmitter receptor activity, coupled via Gs PubMed 
    enables dopamine neurotransmitter receptor activity, coupled via Gs  
    enables heterocyclic compound binding  
    enables heterotrimeric G-protein binding  
    enables heterotrimeric G-protein binding  
    enables protein binding PubMed 
    enables protein phosphatase binding  
    enables protein-containing complex binding  
    enables signaling receptor binding  
    Items 1 - 25 of 99
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-glucose import PubMed 
    involved_in G protein-coupled dopamine receptor signaling pathway  
    acts_upstream_of_or_within G protein-coupled dopamine receptor signaling pathway PubMed 
    acts_upstream_of_or_within G protein-coupled dopamine receptor signaling pathway PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway PubMed 
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway PubMed 
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  
    involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger  
    acts_upstream_of_or_within activation of adenylate cyclase activity PubMed 
    involved_in activation of adenylate cyclase activity  
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
    involved_in adenylate cyclase-activating adrenergic receptor signaling pathway  
    acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway PubMed 
    involved_in adenylate cyclase-activating dopamine receptor signaling pathway PubMed 
    acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway PubMed 
    acts_upstream_of_or_within adenylate cyclase-activating dopamine receptor signaling pathway PubMed 
    involved_in adenylate cyclase-activating dopamine receptor signaling pathway  
    acts_upstream_of_or_within adult walking behavior PubMed 
    acts_upstream_of_or_within adult walking behavior PubMed 
    acts_upstream_of_or_within associative learning PubMed 
    involved_in associative learning  
    acts_upstream_of_or_within astrocyte development PubMed 
    acts_upstream_of_or_within behavioral fear response PubMed 
    acts_upstream_of_or_within behavioral response to cocaine PubMed 
    involved_in behavioral response to cocaine  
    involved_in calcium-mediated signaling  
    acts_upstream_of cell migration PubMed 
    involved_in cellular response to catecholamine stimulus  
    acts_upstream_of_or_within cerebral cortex GABAergic interneuron migration PubMed 
    acts_upstream_of_or_within conditioned taste aversion PubMed 
    acts_upstream_of_or_within dentate gyrus development PubMed 
    acts_upstream_of_or_within dopamine transport PubMed 
    involved_in eating behavior  
    acts_upstream_of_or_within feeding behavior PubMed 
    acts_upstream_of_or_within grooming behavior PubMed 
    involved_in grooming behavior  
    acts_upstream_of_or_within habituation PubMed 
    acts_upstream_of_or_within hippocampus development PubMed 
    involved_in intracellular protein transport  
    acts_upstream_of_or_within learning PubMed 
    acts_upstream_of_or_within locomotory behavior PubMed 
    acts_upstream_of_or_within locomotory behavior PubMed 
    involved_in locomotory behavior  
    acts_upstream_of_or_within long-term synaptic depression PubMed 
    acts_upstream_of_or_within long-term synaptic potentiation PubMed 
    acts_upstream_of_or_within maternal behavior PubMed 
    acts_upstream_of_or_within mating behavior PubMed 
    acts_upstream_of_or_within memory PubMed 
    involved_in modification of postsynaptic structure PubMed 
    involved_in modification of postsynaptic structure PubMed 
    acts_upstream_of_or_within muscle contraction PubMed 
    involved_in negative regulation of cell migration  
    involved_in negative regulation of cellular response to hypoxia  
    involved_in negative regulation of circadian sleep/wake cycle, sleep  
    involved_in negative regulation of synaptic transmission  
    acts_upstream_of neuron migration PubMed 
    acts_upstream_of_or_within neuronal action potential PubMed 
    acts_upstream_of_or_within operant conditioning PubMed 
    involved_in operant conditioning  
    acts_upstream_of_or_within peristalsis PubMed 
    acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway PubMed 
    acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway PubMed 
    acts_upstream_of_or_within phospholipase C-activating dopamine receptor signaling pathway  
    involved_in phospholipase C-activating dopamine receptor signaling pathway  
    involved_in positive regulation of MAPK cascade  
    involved_in positive regulation of feeding behavior  
    involved_in positive regulation of long-term synaptic potentiation  
    involved_in positive regulation of membrane potential  
    acts_upstream_of_or_within positive regulation of neuron migration PubMed 
    involved_in positive regulation of protein phosphorylation  
    involved_in positive regulation of release of sequestered calcium ion into cytosol  
    involved_in positive regulation of release of sequestered calcium ion into cytosol  
    acts_upstream_of_or_within positive regulation of synaptic transmission, glutamatergic PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission  
    NOT acts_upstream_of_or_within prepulse inhibition PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission PubMed 
    involved_in presynaptic modulation of chemical synaptic transmission PubMed 
    acts_upstream_of_or_within protein import into nucleus PubMed 
    acts_upstream_of_or_within protein import into nucleus PubMed 
    acts_upstream_of_or_within protein phosphorylation PubMed 
    acts_upstream_of_or_within regulation of dopamine metabolic process PubMed 
    involved_in regulation of monoatomic ion transport  
    acts_upstream_of_or_within regulation of protein phosphorylation PubMed 
    involved_in regulation of vasoconstriction  
    acts_upstream_of_or_within response to amphetamine PubMed 
    acts_upstream_of_or_within response to amphetamine PubMed 
    acts_upstream_of_or_within response to cocaine PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within response to xenobiotic stimulus PubMed 
    acts_upstream_of_or_within sensitization PubMed 
    involved_in social behavior  
    NOT acts_upstream_of_or_within startle response PubMed 
    acts_upstream_of_or_within striatum development PubMed 
    acts_upstream_of_or_within synaptic transmission, dopaminergic PubMed 
    acts_upstream_of synaptic transmission, glutamatergic PubMed 
    acts_upstream_of_or_within temperature homeostasis PubMed 
    acts_upstream_of_or_within transmission of nerve impulse PubMed 
    involved_in vasodilation  
    acts_upstream_of_or_within visual learning PubMed 
    Items 1 - 25 of 99
    Items 1 - 20 of 34
    Component Evidence Code Pubs
    part_of G protein-coupled receptor complex  
    part_of G protein-coupled receptor complex  
    is_active_in GABA-ergic synapse PubMed 
    located_in axon  
    located_in axon terminus  
    located_in caveola  
    located_in cell surface  
    located_in ciliary membrane  
    located_in ciliary membrane  
    located_in cilium PubMed 
    located_in dendrite  
    located_in dendritic shaft  
    located_in dendritic spine PubMed 
    located_in dendritic spine  
    located_in dendritic spine head  
    located_in dendritic spine neck  
    located_in endomembrane system PubMed 
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum membrane  
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse PubMed 
    is_active_in glutamatergic synapse  
    located_in membrane PubMed 
    located_in neuronal cell body  
    located_in non-motile cilium  
    located_in non-motile cilium  
    located_in nucleus PubMed 
    is_active_in plasma membrane  
    located_in plasma membrane PubMed 
    located_in plasma membrane  
    is_active_in postsynaptic membrane PubMed 
    is_active_in postsynaptic membrane  
    is_active_in presynaptic membrane PubMed 
    is_active_in presynaptic membrane  
    Items 1 - 20 of 34

    General protein information

    Preferred Names
    D(1A) dopamine receptor
    Names
    D1 receptor
    D1A dopamine receptor
    G protein-coupled receptor DRD1
    dopamine D1 receptor
    dopamine receptor D1A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291801.1NP_001278730.1  D(1A) dopamine receptor

      See identical proteins and their annotated locations for NP_001278730.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      BE957273, BY298225, CT030176
      Consensus CDS
      CCDS26524.1
      UniProtKB/Swiss-Prot
      B2RPW8, Q61616, Q8C8P8
      UniProtKB/TrEMBL
      A0A1Y7VK92
      Conserved Domains (2) summary
      pfam00001
      Location:39331
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:40157
      7tm_4; Olfactory receptor
    2. NM_010076.3NP_034206.1  D(1A) dopamine receptor

      See identical proteins and their annotated locations for NP_034206.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK044723, BE957273, BY287823, CT030176
      Consensus CDS
      CCDS26524.1
      UniProtKB/Swiss-Prot
      B2RPW8, Q61616, Q8C8P8
      UniProtKB/TrEMBL
      A0A1Y7VK92
      Related
      ENSMUSP00000021932.6, ENSMUST00000021932.6
      Conserved Domains (2) summary
      pfam00001
      Location:39331
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:40157
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      54205202..54209677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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