Trim16 tripartite motif-containing 16 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Trim16provided by MGI
Official Full Name: tripartite motif-containing 16provided by MGI
Primary source: MGI:MGI:2137356
See related: Ensembl:ENSMUSG00000047821 AllianceGenome:MGI:2137356
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: EBBP; 9130006M08Rik
Summary: Predicted to enable DNA binding activity; NACHT domain binding activity; and interleukin-1 binding activity. Located in cytoplasm. Is expressed in central nervous system and genitourinary system. Orthologous to several human genes including TRIM16 (tripartite motif containing 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in colon adult (RPKM 13.4), lung adult (RPKM 10.4) and 19 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 B2; 11 38.75 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (62711034..62733774)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (62820198..62842948)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIM16 exerts protective function on myocardial ischemia/reperfusion injury through reducing pyroptosis and inflammation via NLRP3 signaling.
Title: TRIM16 exerts protective function on myocardial ischemia/reperfusion injury through reducing pyroptosis and inflammation via NLRP3 signaling.
The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy.
Title: The E3 Ligase TRIM16 Is a Key Suppressor of Pathological Cardiac Hypertrophy.
Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1.
Title: Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1.
TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1.
Title: TRIM16 protects from OGD/R-induced oxidative stress in cultured hippocampal neurons by enhancing Nrf2/ARE antioxidant signaling via downregulation of Keap1.
TRIM16 expression in keratinocytes is involved in cross talk between keratinocytes and melanocytes, and has a role in melanoma tumorigenesis.
Title: Heterozygous loss of keratinocyte TRIM16 expression increases melanocytic cell lesions and lymph node metastasis.
we demonstrate that genetic variation in Trim16 leads to its strain-dependent expression, which alters susceptibility to bleomycin-induced pulmonary fibrosis in mice.
Title: Positional cloning reveals strain-dependent expression of Trim16 to alter susceptibility to bleomycin-induced pulmonary fibrosis in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI482483 (e-PCR)
- UniSTS:165765

47.MMHAP20FRH11.seq (e-PCR)
- UniSTS:186298

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables NACHT domain binding	ISO Inferred from Sequence Orthology more info
enables interleukin-1 binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in PML body	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tripartite motif-containing protein 16

Names: E3 ubiquitin-protein ligase TRIM16; estrogen-responsive B box protein; tripartite motif protein 16

NP_444399.2

EC 2.3.2.27

XP_006534643.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053169.2 → NP_444399.2 tripartite motif-containing protein 16

See identical proteins and their annotated locations for NP_444399.2

Status: VALIDATED

Source sequence(s)

AK053139, AK087112, BB033733

Consensus CDS

CCDS24832.1

UniProtKB/Swiss-Prot

Q7TPY6, Q8C332, Q8C6V0, Q99PP9

UniProtKB/TrEMBL

Q5SVT2

Related

ENSMUSP00000055542.6, ENSMUST00000055006.12

Conserved Domains (2) summary

pfam00643
Location:117 → 157

zf-B_box; B-box zinc finger

cd12890
Location:357 → 538

SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

62711034..62733774

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006534580.5 → XP_006534643.1 tripartite motif-containing protein 16 isoform X1

UniProtKB/Swiss-Prot

Q7TPY6, Q8C332, Q8C6V0, Q99PP9

Related

ENSMUSP00000104343.2, ENSMUST00000108703.2

Conserved Domains (4) summary

pfam05483
Location:87 → 275

SCP-1; Synaptonemal complex protein 1 (SCP-1)

cd12890
Location:270 → 451

SPRY_PRY_TRIM16; PRY/SPRY domain in tripartite motif-containing protein 16 (TRIM16)

cd19769
Location:33 → 78

Bbox2_TRIM16-like; B-box-type 2 zinc finger found in tripartite motif-containing proteins, TRIM16, TRIM29, TRIM47 and similar proteins

cl00034
Location:1 → 26

Bbox_SF; B-box-type zinc finger superfamily