Slc16a3 solute carrier family 16 (monocarboxylic acid transporters), member 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Slc16a3provided by MGI
Official Full Name: solute carrier family 16 (monocarboxylic acid transporters), member 3provided by MGI
Primary source: MGI:MGI:1933438
See related: Ensembl:ENSMUSG00000025161 AllianceGenome:MGI:1933438
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mct3; Mct4
Summary: Enables lactate transmembrane transporter activity. Involved in pyruvate catabolic process. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; early conceptus; gonad; and skeleton. Orthologous to human SLC16A3 (solute carrier family 16 member 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in placenta adult (RPKM 14.2), duodenum adult (RPKM 13.7) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 84.73 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (120839310..120849826)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (120948484..120959000)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.
Title: Monocarboxylate transporter 4 deficiency enhances high-intensity interval training-induced metabolic adaptations in skeletal muscle.
MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus.
Title: MCT4-dependent lactate transport: a novel mechanism for cardiac energy metabolism injury and inflammation in type 2 diabetes mellitus.
Identification of Intron Retention in the Slc16a3 Gene Transcript Encoding the Transporter MCT4 in the Brain of Aged and Alzheimer-Disease Model (APPswePS1dE9) Mice.
Title: Identification of Intron Retention in the Slc16a3 Gene Transcript Encoding the Transporter MCT4 in the Brain of Aged and Alzheimer-Disease Model (APPswePS1dE9) Mice.
Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
Title: Loss of microglial MCT4 leads to defective synaptic pruning and anxiety-like behavior in mice.
MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma.
Title: MCT4-dependent lactate secretion suppresses antitumor immunity in LKB1-deficient lung adenocarcinoma.
Lactate secreted via MCT4 from bonecolonizing breast cancer excites sensory neurons via GPR81.
Title: Lactate secreted via MCT4 from bone‑colonizing breast cancer excites sensory neurons via GPR81.
Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack.
Title: Monocarboxylate transporter 4 inhibition potentiates hepatocellular carcinoma immunotherapy through enhancing T cell infiltration and immune attack.
Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning.
Title: Knockdown of Astrocytic Monocarboxylate Transporter 4 in the Motor Cortex Leads to Loss of Dendritic Spines and a Deficit in Motor Learning.
The MCT4-inhibition-induced disruption of tumor intracellular pH holds promise as a therapy against not only HCC.
Title: Targeted inhibition of MCT4 disrupts intracellular pH homeostasis and confers self-regulated apoptosis on hepatocellular carcinoma.
MCT1 inhibition impairs proliferation of glycolytic breast cancer cells co-expressing MCT1 and MCT4 via disruption of pyruvate rather than lactate export.
Title: MCT1 Modulates Cancer Cell Pyruvate Export and Growth of Tumors that Co-express MCT1 and MCT4.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:461931 (e-PCR)
- UniSTS:461931

Slc16a3 (e-PCR), detects polymorphism
- UniSTS:461931

UniSTS:461932 (e-PCR)
- UniSTS:461932

Slc16a3 (e-PCR), detects polymorphism
- UniSTS:461932

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables lactate transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables lactate:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables lactate:proton symporter activity	ISO Inferred from Sequence Orthology more info
enables lactate:proton symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables pyruvate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables pyruvate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in lactate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in lactate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in plasma membrane lactate transport	ISO Inferred from Sequence Orthology more info
involved_in pyruvate catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in pyruvate transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in pyruvate transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IEA Inferred from Electronic Annotation more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lateral plasma membrane	IEA Inferred from Electronic Annotation more info
located_in lateral plasma membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
is_active_in parallel fiber to Purkinje cell synapse	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: monocarboxylate transporter 4

Names: MCT 4; solute carrier family 16 member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038653.1 → NP_001033742.1 monocarboxylate transporter 4

See identical proteins and their annotated locations for NP_001033742.1

Status: VALIDATED

Source sequence(s)

AK149707, AK166048

Consensus CDS

CCDS25761.1

UniProtKB/Swiss-Prot

P57787, Q9ES80, Q9ESF8

UniProtKB/TrEMBL

Q3TMA0, Q3UDP9

Related

ENSMUSP00000125846.2, ENSMUST00000168579.8

Conserved Domains (1) summary

cd17430
Location:21 → 410

MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters
NM_001038654.1 → NP_001033743.1 monocarboxylate transporter 4

See identical proteins and their annotated locations for NP_001033743.1

Status: VALIDATED

Source sequence(s)

AK149707, AK165596, AK166048

Consensus CDS

CCDS25761.1

UniProtKB/Swiss-Prot

P57787, Q9ES80, Q9ESF8

UniProtKB/TrEMBL

Q3TMA0, Q3UDP9

Related

ENSMUSP00000097706.4, ENSMUST00000100130.10

Conserved Domains (1) summary

cd17430
Location:21 → 410

MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters
NM_030696.3 → NP_109621.1 monocarboxylate transporter 4

See identical proteins and their annotated locations for NP_109621.1

Status: VALIDATED

Source sequence(s)

AK166048, BC046525

Consensus CDS

CCDS25761.1

UniProtKB/Swiss-Prot

P57787, Q9ES80, Q9ESF8

UniProtKB/TrEMBL

Q3TMA0, Q3UDP9

Related

ENSMUSP00000068854.7, ENSMUST00000070653.13

Conserved Domains (1) summary

cd17430
Location:21 → 410

MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

120839310..120849826

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157107.1 → XP_036013000.1 monocarboxylate transporter 4 isoform X1

UniProtKB/Swiss-Prot

P57787, Q9ES80, Q9ESF8

UniProtKB/TrEMBL

Q3TMA0, Q3UDP9

Conserved Domains (1) summary

cd17430
Location:21 → 410

MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters
XM_011249321.3 → XP_011247623.1 monocarboxylate transporter 4 isoform X1

See identical proteins and their annotated locations for XP_011247623.1

UniProtKB/Swiss-Prot

P57787, Q9ES80, Q9ESF8

UniProtKB/TrEMBL

Q3TMA0, Q3UDP9

Conserved Domains (1) summary

cd17430
Location:21 → 410

MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters
XM_011249322.4 → XP_011247624.1 monocarboxylate transporter 4 isoform X1

See identical proteins and their annotated locations for XP_011247624.1

UniProtKB/Swiss-Prot

P57787, Q9ES80, Q9ESF8

UniProtKB/TrEMBL

Q3TMA0, Q3UDP9

Conserved Domains (1) summary

cd17430
Location:21 → 410

MFS_MCT3_4; Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters