Irs3 insulin receptor substrate 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Irs3provided by MGI
Official Full Name: insulin receptor substrate 3provided by MGI
Primary source: MGI:MGI:1194882
See related: Ensembl:ENSMUSG00000047182 AllianceGenome:MGI:1194882
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Enables phosphatidylinositol 3-kinase activator activity and phosphatidylinositol 3-kinase binding activity. Involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in plasma membrane. Is expressed in several structures, including heart; liver; lung; metanephros; and spleen. Orthologous to human IRS3P (insulin receptor substrate 3, pseudogene). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 20.1), mammary gland adult (RPKM 17.0) and 6 other tissues See more
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Genomic context

Location:: 5 G2; 5 76.59 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (137641294..137643976, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (137643032..137645714, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2.
Title: Protein kinase C-zeta phosphorylates insulin receptor substrate-1, -3, and -4 but not -2: isoform specific determinants of specificity in insulin signaling.
These results provide evidences suggesting that IRS-3/PI 3-kinase/PKC zeta signaling is the main responsible for the insulin-induced glucose uptake observed upon differentiation of brown adipocytes lacking IRS-2.
Title: IRS-3 mediates insulin-induced glucose uptake in differentiated IRS-2(-/-) brown adipocytes.
IRS-3 does not play a role compensating for the loss of IRS-2 in maintaining glucose homeostasis and the severity of diabetes in IRS-2(-/-) mice depends upon genetic background
Title: Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice.
These data indicate that both insulin receptor substrate (IRS)-1 and -3, but not IRS-2 or IRS-4, play key roles in the differentiation of brown adipocytes.
Title: Differential roles of insulin receptor substrates in brown adipocyte differentiation.
our study demonstrates that the mIRS-3 promoter is regulated by p53 at the transcriptional level. The inhibition of mIRS-3 promoter by wild-type p53, and its de-repression by tumor-derived p53 mutants
Title: Cloning of the mouse insulin receptor substrate-3 (mIRS-3) promoter, and its regulation by p53.
IRS-3 has a role in the insulin signaling of IRS-1-deficient brown adipocytes but not at the same level as IRS-1
Title: Role of IRS-3 in the insulin signaling of IRS-1-deficient brown adipocytes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

General gene information

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Markers

BE200288 (e-PCR)
- UniSTS:207897

AI558103 (e-PCR)
- UniSTS:165434

PMC86565P2 (e-PCR)
- UniSTS:273535

RH124696 (e-PCR)
- UniSTS:161518

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables insulin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol 3-kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphatidylinositol 3-kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol 3-kinase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: insulin receptor substrate 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_010571.3 → NP_034701.1 insulin receptor substrate 3

See identical proteins and their annotated locations for NP_034701.1

Status: PROVISIONAL

Source sequence(s)

AC124730

Consensus CDS

CCDS19773.1

UniProtKB/TrEMBL

O54718

Related

ENSMUSP00000060844.4, ENSMUST00000057314.4

Conserved Domains (2) summary

cd01204
Location:159 → 273

PTB_IRS; Insulin receptor substrate phosphotyrosine-binding domain (PTBi)

cd01257
Location:31 → 132

PH_IRS; Insulin receptor substrate (IRS) pleckstrin homology (PH) domain