Lrwd1 leucine-rich repeats and WD repeat domain containing 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lrwd1provided by MGI
Official Full Name: leucine-rich repeats and WD repeat domain containing 1provided by MGI
Primary source: MGI:MGI:1918985
See related: Ensembl:ENSMUSG00000029703 AllianceGenome:MGI:1918985
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Orca; 1200011O22Rik
Summary: Predicted to enable chromatin binding activity; methyl-CpG binding activity; and methylated histone binding activity. Predicted to be involved in chromatin organization and establishment of protein localization to chromatin. Predicted to be located in chromosomal region and nuclear lumen. Predicted to be part of nuclear origin of replication recognition complex. Is expressed in embryo. Orthologous to human LRWD1 (leucine rich repeats and WD repeat domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 134.7), thymus adult (RPKM 40.8) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G2; 5 75.8 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (136151920..136164928, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (136123066..136136074, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Lrwd1 impacts cell proliferation and the silencing of repetitive DNA elements.
Title: Lrwd1 impacts cell proliferation and the silencing of repetitive DNA elements.
immunostaining and immunoprecipitation showed colocalization and interaction between lrwd1 and gamma-tubulin respectively, implicating lrwd1 as a candidate centrosomal protein. These results suggest that lrwd1 may play an important role in spermatogenesis.
Title: Expression of lrwd1 in mouse testis and its centrosomal localization.
Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing
Title: Leucine-rich repeat and WD repeat-containing protein 1 is recruited to pericentric heterochromatin by trimethylated lysine 9 of histone H3 and maintains heterochromatin silencing.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables methyl-CpG binding	ISO Inferred from Sequence Orthology more info
enables methyl-CpG binding	ISS Inferred from Sequence or Structural Similarity more info
enables methylated histone binding	ISO Inferred from Sequence Orthology more info
enables methylated histone binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in DNA replication	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in chromatin organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in establishment of protein localization to chromatin	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of protein localization to chromatin	ISO Inferred from Sequence Orthology more info
involved_in establishment of protein localization to chromatin	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, telomeric region	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
part_of nuclear origin of replication recognition complex	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear origin of replication recognition complex	ISO Inferred from Sequence Orthology more info
part_of nuclear origin of replication recognition complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in pericentric heterochromatin	ISO Inferred from Sequence Orthology more info
located_in pericentric heterochromatin	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: leucine-rich repeat and WD repeat-containing protein 1

Names: ORC-associated protein; origin recognition complex-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_027891.4 → NP_082167.2 leucine-rich repeat and WD repeat-containing protein 1

See identical proteins and their annotated locations for NP_082167.2

Status: VALIDATED

Source sequence(s)

AA620153, AK084948, BY142519

Consensus CDS

CCDS51666.1

UniProtKB/Swiss-Prot

D3Z2P9, Q3TIG2, Q8BKI3, Q8BUI3, Q9DBW4

Related

ENSMUSP00000006301.5, ENSMUST00000006301.11

Conserved Domains (6) summary

COG2319
Location:365 → 585

WD40; WD40 repeat [General function prediction only]

sd00031
Location:23 → 48

LRR_1; leucine-rich repeat [structural motif]

pfam12799
Location:47 → 87

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:47 → 103

LRR_8; Leucine rich repeat

sd00039
Location:345 → 391

7WD40; WD40 repeat [structural motif]

cl02567
Location:295 → 585

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...