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    Firrm FIGNL1 interacting regulator of recombination and mitosis [ Mus musculus (house mouse) ]

    Gene ID: 381306, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Firrmprovided by MGI
    Official Full Name
    FIGNL1 interacting regulator of recombination and mitosisprovided by MGI
    Primary source
    MGI:MGI:3590554
    See related
    Ensembl:ENSMUSG00000041406 AllianceGenome:MGI:3590554
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FLIP
    Summary
    Predicted to enable protein kinase binding activity. Predicted to be involved in several processes, including chromosome segregation; interstrand cross-link repair; and regulation of protein kinase activity. Predicted to be located in several cellular components, including kinetochore; midbody; and spindle midzone. Is expressed in testis and thyroid gland. Orthologous to human FIRRM (FIGNL1 interacting regulator of recombination and mitosis). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.4), limb E14.5 (RPKM 5.8) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Firrm in Genome Data Viewer
    Location:
    1 H2.2; 1 71.25 cM
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (163773409..163822377, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (163945993..163994809, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02857 Neighboring gene GC-rich promoter binding protein 1-like 1 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:165709472-165709665 Neighboring gene STARR-seq mESC enhancer starr_02858 Neighboring gene predicted gene, 51663 Neighboring gene kinesin-associated protein 3 Neighboring gene STARR-seq mESC enhancer starr_02859 Neighboring gene SCY1-like 3 (S. cerevisiae) Neighboring gene STARR-positive B cell enhancer ABC_E2015 Neighboring gene STARR-seq mESC enhancer starr_02860 Neighboring gene methyltransferase like 18 Neighboring gene selectin, endothelial cell

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FIGNL1-FIRRM is essential for meiotic recombination and prevents DNA damage-independent RAD51 and DMC1 loading. Zainu A, et al. Nat Commun, 2024 Aug 15. PMID 39147779, Free PMC Article
    2. GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases. van Dam S, et al. BMC Genomics, 2012 Oct 6. PMID 23039964, Free PMC Article
    3. The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart. Zhang Q, et al. Nucleic Acids Res, 2023 Sep 8. PMID 37439366, Free PMC Article
    4. Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells. Asadi F, et al. Front Endocrinol (Lausanne), 2018. PMID 30713523, Free PMC Article
    5. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
      Title: The FLIP-FIGNL1 complex regulates the dissociation of RAD51/DMC1 in homologous recombination and replication fork restart.
    2. BC055324 gene is strongly co-expressed with known cancer-associated genes and with genes involved in the cell cycle.
      Title: GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3)  1 citation
    • Targeted (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC65590

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromosome segregation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interstrand cross-link repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in interstrand cross-link repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in chromosome, centromeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome, centromeric region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle midzone ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    FIGNL1-interacting regulator of recombination and mitosis
    Names
    FIDGETIN-like-1 interacting protein
    POLO1-associating protein
    uncharacterized protein C1orf112 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357049.1 → NP_001343978.1  FIGNL1-interacting regulator of recombination and mitosis isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC110499, AC158964, AK141661
      Consensus CDS
      CCDS87908.1
      Related
      ENSMUSP00000095101.4, ENSMUST00000097493.10
      Conserved Domains (1) summary
      pfam14868
      Location:234 → 779
      DUF4487; Domain of unknown function (DUF4487)

    2. NM_201364.2 → NP_958752.1  FIGNL1-interacting regulator of recombination and mitosis isoform 1

      See identical proteins and their annotated locations for NP_958752.1

      Status: VALIDATED

      Source sequence(s)
      AC110499, AC158964, BC055324
      Consensus CDS
      CCDS35752.1
      UniProtKB/Swiss-Prot
      Q3TQQ9, Q3UR98, Q5RKU3, Q7TMQ3
      Related
      ENSMUSP00000043143.7, ENSMUST00000045876.8
      Conserved Domains (1) summary
      pfam14868
      Location:234 → 779
      DUF4487; Domain of unknown function (DUF4487)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      163773409..163822377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496909.5 → XP_006496972.2  FIGNL1-interacting regulator of recombination and mitosis isoform X1

      Conserved Domains (1) summary
      pfam14868
      Location:234 → 779
      DUF4487; Domain of unknown function (DUF4487)

    RNA

    1. XR_004942956.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TQQ9.2 GenPept UniProtKB/Swiss-Prot:Q3TQQ9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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