Plppr1 phospholipid phosphatase related 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Plppr1provided by MGI
Official Full Name: phospholipid phosphatase related 1provided by MGI
Primary source: MGI:MGI:2445015
See related: Ensembl:ENSMUSG00000063446 AllianceGenome:MGI:2445015
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Lppr1; PRG-3; mKIAA4247; E130309F12Rik
Summary: Predicted to enable phosphatidate phosphatase activity. Predicted to be involved in several processes, including phospholipid dephosphorylation; phospholipid metabolic process; and signal transduction. Predicted to be located in neuron projection and nucleoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including forebrain; forelimb bud; genitourinary system; liver; and notochord. Orthologous to human PLPPR1 (phospholipid phosphatase related 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in CNS E18 (RPKM 9.6), whole brain E14.5 (RPKM 7.1) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 26.27 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (49054986..49340261)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (49059462..49340261)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules.
Title: The lipid phosphatase-like protein PLPPR1 associates with RhoGDI1 to modulate RhoA activation in response to axon growth inhibitory molecules.
Phospholipid phosphatase related 1 (PLPPR1) increases cell adhesion through modulation of Rac1 activity.
Title: Phospholipid phosphatase related 1 (PLPPR1) increases cell adhesion through modulation of Rac1 activity.
This study demonstrated that plasticity-related gene-3 (PRG-3) is differentially expressed between the dorsal and lateral cortex at P6.
Title: Dynamic pattern of mRNA expression of plasticity-related gene-3 (PRG-3) in the mouse cerebral cortex during development.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Markers

D4Mit112 (e-PCR), detects polymorphism
- UniSTS:129886

NoName (e-PCR)
- UniSTS:224613

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables lysophosphatidic acid phosphatase activity	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidate phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
involved_in nervous system development	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in phospholipid dephosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in phospholipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: phospholipid phosphatase-related protein type 1

Names: inactive 2-lysophosphatidate phosphatase PLPPR1; lipid phosphate phosphatase-related protein type 1; plasticity-related gene 3 protein; plasticity-related protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178756.4 → NP_848871.1 phospholipid phosphatase-related protein type 1

See identical proteins and their annotated locations for NP_848871.1

Status: PROVISIONAL

Source sequence(s)

AL691417, AL808138, AL928612, BX537352

Consensus CDS

CCDS18170.1

UniProtKB/Swiss-Prot

Q4V9R3, Q5DTF2, Q8BFZ2, Q8BID2, Q8BIQ1

Related

ENSMUSP00000075966.3, ENSMUST00000076670.3

Conserved Domains (1) summary

cd03384
Location:123 → 272

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

49054986..49340261

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250049.4 → XP_011248351.1 phospholipid phosphatase-related protein type 1 isoform X1

See identical proteins and their annotated locations for XP_011248351.1

UniProtKB/Swiss-Prot

Q4V9R3, Q5DTF2, Q8BFZ2, Q8BID2, Q8BIQ1

Conserved Domains (1) summary

cd03384
Location:123 → 272

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
XM_036164173.1 → XP_036020066.1 phospholipid phosphatase-related protein type 1 isoform X1

UniProtKB/Swiss-Prot

Q4V9R3, Q5DTF2, Q8BFZ2, Q8BID2, Q8BIQ1

Conserved Domains (1) summary

cd03384
Location:123 → 272

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
XM_017320250.3 → XP_017175739.1 phospholipid phosphatase-related protein type 1 isoform X1

UniProtKB/Swiss-Prot

Q4V9R3, Q5DTF2, Q8BFZ2, Q8BID2, Q8BIQ1

Conserved Domains (1) summary

cd03384
Location:123 → 272

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...
XM_006537968.5 → XP_006538031.1 phospholipid phosphatase-related protein type 1 isoform X1

See identical proteins and their annotated locations for XP_006538031.1

UniProtKB/Swiss-Prot

Q4V9R3, Q5DTF2, Q8BFZ2, Q8BID2, Q8BIQ1

Conserved Domains (1) summary

cd03384
Location:123 → 272

PAP2_wunen; PAP2, wunen subfamily. Most likely a family of membrane associated phosphatidic acid phosphatases. Wunen is a drosophila protein expressed in the central nervous system, which provides repellent activity towards primordial germ cells (PGCs), controls the ...