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    Vash1 vasohibin 1 [ Mus musculus (house mouse) ]

    Gene ID: 238328, updated on 9-Dec-2024

    Summary

    Official Symbol
    Vash1provided by MGI
    Official Full Name
    vasohibin 1provided by MGI
    Primary source
    MGI:MGI:2442543
    See related
    Ensembl:ENSMUSG00000021256 AllianceGenome:MGI:2442543
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TTCP 1; D930046M13Rik; G630009D10Rik
    Summary
    Enables actin binding activity and metallocarboxypeptidase activity. Involved in proteolysis. Acts upstream of or within labyrinthine layer blood vessel development and negative regulation of angiogenesis. Predicted to be located in apical part of cell; endoplasmic reticulum; and extracellular space. Predicted to be active in cytoplasm. Is expressed in nervous system and retina. Human ortholog(s) of this gene implicated in liver cirrhosis and portal hypertension. Orthologous to human VASH1 (vasohibin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in whole brain E14.5 (RPKM 15.3), CNS E14 (RPKM 13.4) and 16 other tissues See more
    Orthologs
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    Genomic context

    See Vash1 in Genome Data Viewer
    Location:
    12 D2; 12 40.84 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (86725474..86742462)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (86678700..86695688)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene poly(rC) binding protein 2 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr12:88000594-88000875 Neighboring gene predicted gene, 22004 Neighboring gene STARR-seq mESC enhancer starr_32830 Neighboring gene angel homolog 1 Neighboring gene pyruvate kinase, muscle pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5342 Neighboring gene predicted gene, 32755

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding PubMed 
    enables actin binding  
    enables metallocarboxypeptidase activity PubMed 
    enables metallocarboxypeptidase activity  
    enables protein binding PubMed 
    enables tubulin-tyrosine carboxypeptidase  
    Process Evidence Code Pubs
    acts_upstream_of_or_within angiogenesis PubMed 
    acts_upstream_of_or_within labyrinthine layer blood vessel development PubMed 
    acts_upstream_of_or_within negative regulation of angiogenesis PubMed 
    acts_upstream_of_or_within negative regulation of angiogenesis PubMed 
    acts_upstream_of_or_within negative regulation of angiogenesis  
    involved_in negative regulation of angiogenesis  
    involved_in negative regulation of blood vessel endothelial cell migration  
    involved_in negative regulation of blood vessel endothelial cell migration  
    acts_upstream_of_or_within negative regulation of endothelial cell migration  
    acts_upstream_of_or_within negative regulation of endothelial cell proliferation PubMed 
    involved_in negative regulation of endothelial cell proliferation  
    acts_upstream_of_or_within negative regulation of lymphangiogenesis PubMed 
    acts_upstream_of_or_within placenta blood vessel development PubMed 
    acts_upstream_of_or_within positive regulation of gene expression PubMed 
    involved_in proteolysis PubMed 
    involved_in proteolysis  
    involved_in regulation of angiogenesis  
    involved_in regulation of cell cycle  
    acts_upstream_of_or_within regulation of cellular senescence PubMed 
    acts_upstream_of_or_within response to wounding PubMed 
    Component Evidence Code Pubs
    located_in apical part of cell  
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in endoplasmic reticulum  
    located_in endoplasmic reticulum  
    located_in extracellular space  

    General protein information

    Preferred Names
    tubulinyl-Tyr carboxypeptidase 1
    Names
    tyrosine carboxypeptidase 1
    NP_796328.2
    XP_011242409.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177354.4NP_796328.2  tubulinyl-Tyr carboxypeptidase 1

      See identical proteins and their annotated locations for NP_796328.2

      Status: VALIDATED

      Source sequence(s)
      AC102689
      Consensus CDS
      CCDS49118.1
      UniProtKB/Swiss-Prot
      E9QKT9, Q8C1W1, Q8C394
      UniProtKB/TrEMBL
      A0PCF8
      Related
      ENSMUSP00000021681.4, ENSMUST00000021681.4
      Conserved Domains (1) summary
      pfam14822
      Location:68312
      Vasohibin; Vasohibin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      86725474..86742462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011244107.4XP_011242409.1  tubulinyl-Tyr carboxypeptidase 1 isoform X1

      See identical proteins and their annotated locations for XP_011242409.1

      Conserved Domains (1) summary
      pfam14822
      Location:1149
      Vasohibin
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