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    Rnase6 ribonuclease, RNase A family, 6 [ Mus musculus (house mouse) ]

    Gene ID: 78416, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rnase6provided by MGI
    Official Full Name
    ribonuclease, RNase A family, 6provided by MGI
    Primary source
    MGI:MGI:1925666
    See related
    Ensembl:ENSMUSG00000021880 AllianceGenome:MGI:1925666
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9530043P15Rik
    Summary
    Predicted to enable RNA nuclease activity. Involved in defense response to other organism. Located in extracellular space. Orthologous to human RNASE6 (ribonuclease A family member 6). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in spleen adult (RPKM 17.8), mammary gland adult (RPKM 6.0) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Rnase6 in Genome Data Viewer
    Location:
    14 C1; 14 26.39 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (51361365..51369644)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (51123908..51132187)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ribonuclease, RNase A family 4 Neighboring gene STARR-positive B cell enhancer ABC_E4108 Neighboring gene angiogenin, ribonuclease, RNase A family, 5 Neighboring gene epididymal protein 3B Neighboring gene STARR-positive B cell enhancer ABC_E9895 Neighboring gene ribonuclease, RNase A family, 1 (pancreatic) Neighboring gene ribonuclease, RNase A family, 2B (liver, eosinophil-derived neurotoxin)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA nuclease activity  
    enables RNA nuclease activity  
    enables endonuclease activity  
    enables nucleic acid binding  
    Process Evidence Code Pubs
    involved_in antibacterial humoral response  
    involved_in antibacterial humoral response PubMed 
    involved_in antibacterial humoral response  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide PubMed 
    involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
    involved_in defense response to Gram-negative bacterium  
    involved_in defense response to Gram-negative bacterium PubMed 
    involved_in defense response to Gram-negative bacterium  
    involved_in defense response to Gram-positive bacterium  
    involved_in defense response to Gram-positive bacterium PubMed 
    involved_in defense response to Gram-positive bacterium  
    involved_in defense response to virus  
    involved_in innate immune response  
    involved_in innate immune response PubMed 
    involved_in innate immune response  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in lysosome  

    General protein information

    Preferred Names
    ribonuclease K6
    Names
    RNase K6
    ribonuclease A family, member 6
    NP_001347046.1
    NP_084374.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360117.1NP_001347046.1  ribonuclease K6

      Status: VALIDATED

      Source sequence(s)
      AK038708, BG091045
      Consensus CDS
      CCDS27037.1
      UniProtKB/Swiss-Prot
      A2RTT6, Q6QDX5, Q9D244
      UniProtKB/TrEMBL
      Q3V3L3, W0UTF2
      Related
      ENSMUSP00000154125.2, ENSMUST00000226194.2
      Conserved Domains (1) summary
      pfam00074
      Location:33150
      RnaseA; Pancreatic ribonuclease
    2. NM_030098.3NP_084374.2  ribonuclease K6

      See identical proteins and their annotated locations for NP_084374.2

      Status: VALIDATED

      Source sequence(s)
      AA182060, AK020595, AK038708, BG091045
      Consensus CDS
      CCDS27037.1
      UniProtKB/Swiss-Prot
      A2RTT6, Q6QDX5, Q9D244
      UniProtKB/TrEMBL
      Q3V3L3, W0UTF2
      Related
      ENSMUSP00000093613.4, ENSMUST00000095923.4
      Conserved Domains (1) summary
      pfam00074
      Location:33150
      RnaseA; Pancreatic ribonuclease

    RNA

    1. NR_153407.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AA182060, AK038708, BE687377, BG091045

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      51361365..51369644
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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