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    Map7 microtubule-associated protein 7 [ Mus musculus (house mouse) ]

    Gene ID: 17761, updated on 9-Dec-2024

    Summary

    Official Symbol
    Map7provided by MGI
    Official Full Name
    microtubule-associated protein 7provided by MGI
    Primary source
    MGI:MGI:1328328
    See related
    Ensembl:ENSMUSG00000019996 AllianceGenome:MGI:1328328
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ste; mshi; mste; MAP-7; Mtap7; E-MAP-115
    Summary
    Enables signaling receptor binding activity. Involved in protein localization to plasma membrane and response to osmotic stress. Acts upstream of or within several processes, including glycosphingolipid metabolic process; male gonad development; and response to retinoic acid. Located in plasma membrane. Is expressed in several structures, including alimentary system; endocrine gland; genitourinary system; nervous system; and skin. Orthologous to human MAP7 (microtubule associated protein 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 10.3), cortex adult (RPKM 7.2) and 27 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Map7 in Genome Data Viewer
    Location:
    10 A3; 10 9.75 cM
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (20024666..20157336)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (20148920..20281590)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_25941 Neighboring gene STARR-seq mESC enhancer starr_25942 Neighboring gene peroxisomal biogenesis factor 7 Neighboring gene STARR-seq mESC enhancer starr_25943 Neighboring gene STARR-positive B cell enhancer ABC_E10597 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19659120-19659310 Neighboring gene mitogen-activated protein kinase kinase kinase 5 Neighboring gene STARR-seq mESC enhancer starr_25945 Neighboring gene STARR-positive B cell enhancer mm9_chr10:19711687-19711987 Neighboring gene STARR-positive B cell enhancer ABC_E8326 Neighboring gene STARR-positive B cell enhancer ABC_E11432 Neighboring gene STARR-seq mESC enhancer starr_25946 Neighboring gene STARR-seq mESC enhancer starr_25947 Neighboring gene STARR-seq mESC enhancer starr_25949 Neighboring gene STARR-seq mESC enhancer starr_25952 Neighboring gene RIKEN cDNA 4930405J17 gene Neighboring gene predicted gene, 51795 Neighboring gene STARR-seq mESC enhancer starr_25958 Neighboring gene ribosomal protein L32-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:19977636-19977875 Neighboring gene predicted gene, 48249 Neighboring gene predicted gene, 30285 Neighboring gene microRNA 6413

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (5 hits/77 screens)

    Associated conditions

    Description Tests
    male sterility and histoincompatibility
    GeneReviews: Not available

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding PubMed 
    enables signaling receptor binding PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within Leydig cell differentiation PubMed 
    acts_upstream_of_or_within Sertoli cell development PubMed 
    acts_upstream_of_or_within cell morphogenesis PubMed 
    acts_upstream_of_or_within cell population proliferation PubMed 
    acts_upstream_of_or_within fertilization PubMed 
    acts_upstream_of_or_within germ cell development PubMed 
    acts_upstream_of_or_within glycosphingolipid metabolic process PubMed 
    acts_upstream_of_or_within homeostasis of number of cells PubMed 
    acts_upstream_of_or_within microtubule bundle formation PubMed 
    involved_in microtubule cytoskeleton organization  
    acts_upstream_of_or_within nucleus organization PubMed 
    acts_upstream_of_or_within organ growth PubMed 
    involved_in protein localization to plasma membrane PubMed 
    involved_in response to osmotic stress PubMed 
    acts_upstream_of_or_within response to osmotic stress PubMed 
    acts_upstream_of_or_within response to retinoic acid PubMed 
    acts_upstream_of_or_within spermatogenesis PubMed 
    Component Evidence Code Pubs
    located_in axon  
    located_in basolateral plasma membrane  
    located_in cytosol  
    located_in microtubule  
    is_active_in microtubule cytoskeleton  
    located_in microtubule cytoskeleton  
    located_in perinuclear region of cytoplasm  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    ensconsin
    Names
    epithelial microtubule-associated protein of 115 kDa

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198635.2NP_001185564.1  ensconsin isoform 2

      See identical proteins and their annotated locations for NP_001185564.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate splice site in the CDS, as compared to variant 1. The resulting isoform (2) has an additional segment, as compared to isoform 1.
      Source sequence(s)
      AC153845, AC158620
      Consensus CDS
      CCDS56694.1
      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      UniProtKB/TrEMBL
      D3YWN7
      Related
      ENSMUSP00000111963.4, ENSMUST00000116259.5
      Conserved Domains (1) summary
      pfam05672
      Location:458610
      MAP7; MAP7 (E-MAP-115) family
    2. NM_001358787.1NP_001345716.1  ensconsin isoform 3

      Status: VALIDATED

      Source sequence(s)
      AB098611, AK014575, BC052637, BY264190
      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (3) summary
      pfam03999
      Location:111337
      MAP65_ASE1; Microtubule associated protein (MAP65/ASE1 family)
      pfam05672
      Location:472625
      MAP7; MAP7 (E-MAP-115) family
      pfam09756
      Location:101174
      DDRGK; DDRGK domain
    3. NM_001428647.1NP_001415576.1  ensconsin isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620
      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
    4. NM_001428648.1NP_001415577.1  ensconsin isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620
      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
    5. NM_001428649.1NP_001415578.1  ensconsin isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620
      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
    6. NM_001428650.1NP_001415579.1  ensconsin isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620
      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
    7. NM_001428651.1NP_001415580.1  ensconsin isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620
      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
    8. NM_001428652.1NP_001415581.1  ensconsin isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620
    9. NM_001428653.1NP_001415582.1  ensconsin isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620
    10. NM_001428654.1NP_001415583.1  ensconsin isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620
    11. NM_001428655.1NP_001415584.1  ensconsin isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620
      UniProtKB/TrEMBL
      A0A1L1SVB6
    12. NM_001428656.1NP_001415585.1  ensconsin isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC153845, AC158620
    13. NM_008635.3NP_032661.2  ensconsin isoform 1

      See identical proteins and their annotated locations for NP_032661.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the dominant transcript and encodes isoform 1.
      Source sequence(s)
      AC153845, AC158620
      Consensus CDS
      CCDS87968.1
      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      UniProtKB/TrEMBL
      E9QMU3
      Related
      ENSMUSP00000020173.10, ENSMUST00000020173.16
      Conserved Domains (1) summary
      pfam05672
      Location:450602
      MAP7; MAP7 (E-MAP-115) family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      20024666..20157336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036155666.1XP_036011559.1  ensconsin isoform X8

      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (1) summary
      pfam05672
      Location:312464
      MAP7; MAP7 (E-MAP-115) family
    2. XM_006512577.4XP_006512640.1  ensconsin isoform X1

      Conserved Domains (2) summary
      pfam05672
      Location:480632
      MAP7; MAP7 (E-MAP-115) family
      pfam15927
      Location:111180
      Casc1_N; Cancer susceptibility candidate 1 N-terminus
    3. XM_036155665.1XP_036011558.1  ensconsin isoform X4

      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (2) summary
      pfam05672
      Location:442594
      MAP7; MAP7 (E-MAP-115) family
      pfam06098
      Location:111168
      Radial_spoke_3; Radial spoke protein 3
    4. XM_006512582.4XP_006512645.1  ensconsin isoform X6

      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (2) summary
      pfam05672
      Location:434586
      MAP7; MAP7 (E-MAP-115) family
      pfam15927
      Location:111180
      Casc1_N; Cancer susceptibility candidate 1 N-terminus
    5. XM_036155667.1XP_036011560.1  ensconsin isoform X9

      Conserved Domains (1) summary
      pfam05672
      Location:274426
      MAP7; MAP7 (E-MAP-115) family
    6. XM_006512584.5XP_006512647.1  ensconsin isoform X8

      Conserved Domains (1) summary
      pfam05672
      Location:312464
      MAP7; MAP7 (E-MAP-115) family
    7. XM_006512585.5XP_006512648.1  ensconsin isoform X8

      See identical proteins and their annotated locations for XP_006512648.1

      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (1) summary
      pfam05672
      Location:312464
      MAP7; MAP7 (E-MAP-115) family
    8. XM_006512580.3XP_006512643.1  ensconsin isoform X3

      Conserved Domains (2) summary
      pfam05672
      Location:443595
      MAP7; MAP7 (E-MAP-115) family
      pfam15927
      Location:74145
      Casc1_N; Cancer susceptibility candidate 1 N-terminus
    9. XM_006512581.3XP_006512644.1  ensconsin isoform X5

      Conserved Domains (2) summary
      pfam05672
      Location:435587
      MAP7; MAP7 (E-MAP-115) family
      pfam15927
      Location:74143
      Casc1_N; Cancer susceptibility candidate 1 N-terminus
    10. XM_006512583.4XP_006512646.1  ensconsin isoform X7

      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (2) summary
      pfam05672
      Location:421573
      MAP7; MAP7 (E-MAP-115) family
      pfam15927
      Location:98167
      Casc1_N; Cancer susceptibility candidate 1 N-terminus
    11. XM_006512579.4XP_006512642.1  ensconsin isoform X2

      UniProtKB/Swiss-Prot
      O88735, Q3V0B9, Q7TQL9, Q80V60
      Conserved Domains (2) summary
      pfam05672
      Location:467619
      MAP7; MAP7 (E-MAP-115) family
      pfam09756
      Location:88161
      DDRGK; DDRGK domain
    12. XM_036155668.1XP_036011561.1  ensconsin isoform X10

      Conserved Domains (1) summary
      pfam05672
      Location:193345
      MAP7; MAP7 (E-MAP-115) family

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