Usp29 ubiquitin specific peptidase 29 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Usp29provided by MGI
Official Full Name: ubiquitin specific peptidase 29provided by MGI
Primary source: MGI:MGI:1888998
See related: Ensembl:ENSMUSG00000051527 AllianceGenome:MGI:1888998
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ocat
Summary: Enables cysteine-type endopeptidase activity. Involved in several processes, including positive regulation of type I interferon-mediated signaling pathway; protein K48-linked deubiquitination; and protein stabilization. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including brain; limb bud; testis; and trunk. Orthologous to human USP29 (ubiquitin specific peptidase 29). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in CNS E18 (RPKM 4.9), whole brain E14.5 (RPKM 4.2) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 A1; 7 4.04 cM

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (6733560..6970219)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (6730559..6967220)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-beta-activated kinase 1 deubiquitination.
Title: Ubiquitin-specific protease 29 attenuates hepatic ischemia-reperfusion injury by mediating TGF-β-activated kinase 1 deubiquitination.
Extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2.
Title: Extracellular vesicles derived from melatonin-preconditioned mesenchymal stem cells containing USP29 repair traumatic spinal cord injury by stabilizing NRF2.
USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.
Title: USP29 maintains the stability of cGAS and promotes cellular antiviral responses and autoimmunity.
USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress.
Title: USP29 enhances chemotherapy-induced stemness in non-small cell lung cancer via stabilizing Snail1 in response to oxidative stress.
Ubiquitin-specific processing protease 29 (Usp29) shows predominant expression in mouse testis. Usp29 knockout mice (Usp29(-/-)) have normal fertility and show no detectable difference in the testis/body weight ratio, testicular and epididymal histology as well as epididymal sperm count from the wild-type littermates.
Title: The deubiquitinating gene Usp29 is dispensable for fertility in male mice.
The mutants with abrogation of the two paternally expressed genes, Peg3 and Usp29, showed a significant decrease in growth rates for both males and females, while the mutants with biallelic expression of Peg3 and Usp29 resulted in an increased growth rate of female mice only
Title: Allele and dosage specificity of the Peg3 imprinted domain.
the transcription of Usp29 may be involved in DNA methylation setting of Zfp264 promoter in a sex-specific manner.
Title: Transcriptional Truncation of the Long Coding Imprinted Gene Usp29.
Conserved Sequence Element 2 (YY1 binding sites),functions as an activator for Peg3 transcription, while Conserved Sequence Element 1 acts as a repressor for the transcription of both Peg3 and Usp29.
Title: Two evolutionarily conserved sequence elements for Peg3/Usp29 transcription.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (3) 1 citation
Endonuclease-mediated (4) 1 citation
Targeted (2) 1 citation

General gene information

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Markers

RH135927 (e-PCR)
- UniSTS:209924

PMC310910P1 (e-PCR)
- UniSTS:272809

Usp29 (e-PCR), detects polymorphism
- UniSTS:167639

Usp29 (e-PCR), detects polymorphism
- UniSTS:527849

Usp29 (e-PCR), detects polymorphism
- UniSTS:527850

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type I interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in protein K48-linked deubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein stabilization	IDA Inferred from Direct Assay more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein stability	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ubiquitin carboxyl-terminal hydrolase 29

Names: ASL1/Usp29 fusion; deubiquitinating enzyme 29; ossification center-associated transcript; ubiquitin thioesterase 29; ubiquitin thiolesterase 29; ubiquitin-specific-processing protease 29

NP_001277923.1

EC 3.4.19.12

NP_001347430.1

EC 3.4.19.12

NP_001347431.1

EC 3.4.19.12

NP_001407092.1

EC 3.4.19.12

NP_001407093.1

EC 3.4.19.12

NP_067298.2

EC 3.4.19.12

XP_011248964.1

EC 3.4.19.12

XP_017177905.1

EC 3.4.19.12

XP_017177906.1

EC 3.4.19.12

XP_030098699.1

EC 3.4.19.12

XP_036009191.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290994.1 → NP_001277923.1 ubiquitin carboxyl-terminal hydrolase 29

See identical proteins and their annotated locations for NP_001277923.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.

Source sequence(s)

AC149277, AC157657

Consensus CDS

CCDS20784.1

UniProtKB/Swiss-Prot

C6EQG1, Q9ES63

Related

ENSMUSP00000143769.3, ENSMUST00000200535.6

Conserved Domains (3) summary

cd13312
Location:4 → 109

PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37

pfam00443
Location:290 → 540

UCH; Ubiquitin carboxyl-terminal hydrolase

cl02553
Location:763 → 823

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
NM_001360501.2 → NP_001347430.1 ubiquitin carboxyl-terminal hydrolase 29

Status: VALIDATED

Source sequence(s)

AC149277, AC157657

Consensus CDS

CCDS20784.1

UniProtKB/Swiss-Prot

C6EQG1, Q9ES63

Conserved Domains (3) summary

cd13312
Location:4 → 109

PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37

pfam00443
Location:290 → 540

UCH; Ubiquitin carboxyl-terminal hydrolase

cl02553
Location:763 → 823

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
NM_001360502.2 → NP_001347431.1 ubiquitin carboxyl-terminal hydrolase 29

Status: VALIDATED

Source sequence(s)

AC149277, AC157657

Consensus CDS

CCDS20784.1

UniProtKB/Swiss-Prot

C6EQG1, Q9ES63

Conserved Domains (3) summary

cd13312
Location:4 → 109

PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37

pfam00443
Location:290 → 540

UCH; Ubiquitin carboxyl-terminal hydrolase

cl02553
Location:763 → 823

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
NM_001420163.1 → NP_001407092.1 ubiquitin carboxyl-terminal hydrolase 29

Status: VALIDATED

Source sequence(s)

AC149277, AC157657

UniProtKB/Swiss-Prot

C6EQG1, Q9ES63
NM_001420164.1 → NP_001407093.1 ubiquitin carboxyl-terminal hydrolase 29

Status: VALIDATED

Source sequence(s)

AC149277, AC157657

UniProtKB/Swiss-Prot

C6EQG1, Q9ES63
NM_021323.4 → NP_067298.2 ubiquitin carboxyl-terminal hydrolase 29

See identical proteins and their annotated locations for NP_067298.2

Status: VALIDATED

Source sequence(s)

AC149277, AC157657

Consensus CDS

CCDS20784.1

UniProtKB/Swiss-Prot

C6EQG1, Q9ES63

Conserved Domains (3) summary

cd13312
Location:4 → 109

PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37

pfam00443
Location:290 → 540

UCH; Ubiquitin carboxyl-terminal hydrolase

cl02553
Location:763 → 823

Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...

RNA

NR_153505.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC149277, AC157657
NR_153506.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC149277, AC157657
NR_153507.2 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC157657

Related

ENSMUST00000207899.2
NR_153590.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (8) differs in the 3' end compared to variant 1. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.

Source sequence(s)

AC157657, BC063090

Related

ENSMUST00000208662.2
NR_185143.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC149277, AC157657
NR_185144.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC149277, AC157657
NR_185145.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC149277, AC157657
NR_185146.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC149277, AC157657
NR_185147.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC157657

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

6733560..6970219

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011250662.3 → XP_011248964.1 ubiquitin carboxyl-terminal hydrolase 29 isoform X1

Conserved Domains (3) summary

COG5207
Location:297 → 830

UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]

cd13312
Location:11 → 116

PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37

pfam00443
Location:297 → 547

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_030242839.2 → XP_030098699.1 ubiquitin carboxyl-terminal hydrolase 29 isoform X1

Conserved Domains (3) summary

COG5207
Location:297 → 830

UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]

cd13312
Location:11 → 116

PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37

pfam00443
Location:297 → 547

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_017322416.2 → XP_017177905.1 ubiquitin carboxyl-terminal hydrolase 29 isoform X1

Conserved Domains (3) summary

COG5207
Location:297 → 830

UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]

cd13312
Location:11 → 116

PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37

pfam00443
Location:297 → 547

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_017322417.2 → XP_017177906.1 ubiquitin carboxyl-terminal hydrolase 29 isoform X1

Conserved Domains (3) summary

COG5207
Location:297 → 830

UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]

cd13312
Location:11 → 116

PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37

pfam00443
Location:297 → 547

UCH; Ubiquitin carboxyl-terminal hydrolase
XM_036153298.1 → XP_036009191.1 ubiquitin carboxyl-terminal hydrolase 29 isoform X1

Related

ENSMUSP00000143267.3, ENSMUST00000198068.3

Conserved Domains (3) summary

COG5207
Location:297 → 830

UBP14; Uncharacterized Zn-finger protein, UBP-type [General function prediction only]

cd13312
Location:11 → 116

PH_USP37_like; Pleckstrin homology-like domain of Ubiquitin carboxyl-terminal hydrolase 37

pfam00443
Location:297 → 547

UCH; Ubiquitin carboxyl-terminal hydrolase