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    Rnf43 ring finger protein 43 [ Mus musculus (house mouse) ]

    Gene ID: 207742, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rnf43provided by MGI
    Official Full Name
    ring finger protein 43provided by MGI
    Primary source
    MGI:MGI:2442609
    See related
    Ensembl:ENSMUSG00000034177 AllianceGenome:MGI:2442609
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732452J19Rik
    Summary
    Predicted to enable frizzled binding activity and ubiquitin protein ligase activity. Involved in negative regulation of Wnt signaling pathway and stem cell proliferation. Predicted to be located in endoplasmic reticulum membrane and nuclear envelope. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; forelimb epidermis; genitourinary system; lung; and submandibular gland primordium. Human ortholog(s) of this gene implicated in endometrial cancer; gastrointestinal system cancer (multiple); irritable bowel syndrome; lung adenocarcinoma; and villous adenoma. Orthologous to human RNF43 (ring finger protein 43). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in duodenum adult (RPKM 7.3), colon adult (RPKM 5.7) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Rnf43 in Genome Data Viewer
    Location:
    11 C; 11 52.17 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87553913..87626365)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (87663087..87735539)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E68 Neighboring gene STARR-seq mESC enhancer starr_30293 Neighboring gene myotubularin related protein 4 Neighboring gene heat shock transcription factor family member 5 Neighboring gene STARR-positive B cell enhancer ABC_E5260 Neighboring gene STARR-seq mESC enhancer starr_30296 Neighboring gene RIKEN cDNA 1110028F11 gene Neighboring gene predicted gene, 25968 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87534506-87534735 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87539623-87539928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87547776-87547885 Neighboring gene STARR-positive B cell enhancer ABC_E7039 Neighboring gene STARR-positive B cell enhancer ABC_E1838 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87563093-87563276 Neighboring gene SPT4A, DSIF elongation factor subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87565164-87565417 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87568144-87568342 Neighboring gene STARR-positive B cell enhancer ABC_E8440 Neighboring gene microRNA 142b Neighboring gene microRNA 142

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selective epigenetic alterations in RNF43 in pancreatic exocrine cells from high-fat-diet-induced obese mice; implications for pancreatic cancer. Araki T, et al. BMC Res Notes, 2024 Apr 15. PMID 38622664, Free PMC Article
    2. JAK-STAT1 Signaling Pathway Is an Early Response to Helicobacter pylori Infection and Contributes to Immune Escape and Gastric Carcinogenesis. Li X, et al. Int J Mol Sci, 2022 Apr 8. PMID 35456965, Free PMC Article
    3. Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation. Zhou X, et al. Animal Model Exp Med, 2022 Feb. PMID 35229994, Free PMC Article
    4. Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma. Hosein AN, et al. Gastroenterology, 2022 Apr. PMID 34973294, Free PMC Article
    5. A DNA repair player, ring finger protein 43, relieves etoposide-induced topoisomerase II poisoning. Lerksuthirat T, et al. Genes Cells, 2020 Nov. PMID 32939879

    See all (44) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Selective epigenetic alterations in RNF43 in pancreatic exocrine cells from high-fat-diet-induced obese mice; implications for pancreatic cancer.
      Title: Selective epigenetic alterations in RNF43 in pancreatic exocrine cells from high-fat-diet-induced obese mice; implications for pancreatic cancer.
    2. RNF43 induces the turnover of protease-activated receptor 2 in colon cancer.
      Title: RNF43 induces the turnover of protease-activated receptor 2 in colon cancer.
    3. Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma.
      Title: Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma.
    4. RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
      Title: RNF43/ZNRF3 negatively regulates taste tissue homeostasis and positively regulates dorsal lingual epithelial tissue homeostasis.
    5. Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage Response.
      Title: Loss of RNF43 Function Contributes to Gastric Carcinogenesis by Impairing DNA Damage Response.
    6. Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation.
      Title: Deficient Rnf43 potentiates hyperactive Kras-mediated pancreatic preneoplasia initiation and malignant transformation.
    7. ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.
      Title: ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation.
    8. A DNA repair player, ring finger protein 43, relieves etoposide-induced topoisomerase II poisoning.
      Title: A DNA repair player, ring finger protein 43, relieves etoposide-induced topoisomerase II poisoning.
    9. Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma.
      Title: Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma.
    10. A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
      Title: A phospho-switch controls RNF43-mediated degradation of Wnt receptors to suppress tumorigenesis.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables frizzled binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables frizzled binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-protein transferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in Wnt receptor catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Wnt receptor catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Wnt receptor catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in stem cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase RNF43
    Names
    RING-type E3 ubiquitin transferase RNF43
    NP_001350366.1
    NP_766036.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001363437.1 → NP_001350366.1  E3 ubiquitin-protein ligase RNF43 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK028750, AL604022
      Consensus CDS
      CCDS88216.1
      UniProtKB/TrEMBL
      A3KMI3, E9PWJ5
      Related
      ENSMUSP00000044241.5, ENSMUST00000040089.5
      Conserved Domains (2) summary
      cd16798
      Location:143 → 189
      RING-H2_RNF43; RING finger, H2 subclass, found in RING finger protein 43 (RNF43) and similar proteins
      cl28271
      Location:472 → 629
      dnaA; chromosomal replication initiation protein; Provisional

    2. NM_172448.4 → NP_766036.2  E3 ubiquitin-protein ligase RNF43 isoform 1 precursor

      See identical proteins and their annotated locations for NP_766036.2

      Status: VALIDATED

      Source sequence(s)
      AK032782, BC131957, CF747567
      Consensus CDS
      CCDS25215.2
      UniProtKB/Swiss-Prot
      B2KGH3, Q5NCP0, Q6DI76, Q8BME0, Q8C191, Q8K0X4
      UniProtKB/TrEMBL
      E9PWJ5
      Related
      ENSMUSP00000130685.2, ENSMUST00000165679.8
      Conserved Domains (1) summary
      pfam13639
      Location:270 → 312
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87553913..87626365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5NCP0.1 GenPept UniProtKB/Swiss-Prot:Q5NCP0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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