U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    S100a1 S100 calcium binding protein A1 [ Mus musculus (house mouse) ]

    Gene ID: 20193, updated on 9-Dec-2024

    Summary

    Official Symbol
    S100a1provided by MGI
    Official Full Name
    S100 calcium binding protein A1provided by MGI
    Primary source
    MGI:MGI:1338917
    See related
    Ensembl:ENSMUSG00000044080 AllianceGenome:MGI:1338917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    S100; S100a
    Summary
    Predicted to enable several functions, including ATPase binding activity; S100 protein binding activity; and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; positive regulation of nitric-oxide synthase activity; and positive regulation of sprouting angiogenesis. Located in sarcoplasmic reticulum. Is expressed in several structures, including brain; heart; inner ear; musculature; and urothelium. Orthologous to human S100A1 (S100 calcium binding protein A1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in heart adult (RPKM 436.8), kidney adult (RPKM 243.2) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See S100a1 in Genome Data Viewer
    Location:
    3 F1; 3 39.24 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (90418341..90421637, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (90511034..90514330, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene interleukin enhancer binding factor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2084 Neighboring gene SNAP-associated protein Neighboring gene chromatin target of PRMT1 Neighboring gene STARR-positive B cell enhancer ABC_E2085 Neighboring gene STARR-seq mESC enhancer starr_08290 Neighboring gene S100 calcium binding protein A13 Neighboring gene S100 calcium binding protein A14 Neighboring gene S100 calcium binding protein A16

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase binding  
    enables S100 protein binding  
    enables S100 protein binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium ion binding  
    enables calcium-dependent protein binding  
    enables calcium-dependent protein binding  
    enables identical protein binding  
    enables protein binding PubMed 
    enables protein homodimerization activity  
    Component Evidence Code Pubs
    located_in A band  
    located_in Golgi apparatus  
    located_in I band  
    located_in M band  
    located_in Z disc  
    is_active_in cytoplasm  
    located_in cytosol  
    located_in mitochondrion  
    located_in nucleoplasm  
    located_in nucleus  
    is_active_in sarcoplasmic reticulum  
    located_in sarcoplasmic reticulum PubMed 
    located_in sarcoplasmic reticulum  

    General protein information

    Preferred Names
    protein S100-A1
    Names
    S-100 protein alpha chain
    S-100 protein subunit alpha

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_011309.3NP_035439.1  protein S100-A1

      See identical proteins and their annotated locations for NP_035439.1

      Status: VALIDATED

      Source sequence(s)
      AK012578, AK168822
      Consensus CDS
      CCDS38503.1
      UniProtKB/Swiss-Prot
      O88949, P56565
      UniProtKB/TrEMBL
      Q91V77, Q9D3M4
      Related
      ENSMUSP00000058237.9, ENSMUST00000060738.9
      Conserved Domains (2) summary
      cd05025
      Location:292
      S-100A1; S-100A1: S-100A1 domain found in proteins similar to S100A1. S100A1 is a calcium-binding protein belonging to a large S100 vertebrate-specific protein family within the EF-hand superfamily of calcium-binding proteins. Note that the S-100 hierarchy, to ...
      pfam13499
      Location:2876
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      90418341..90421637 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    External link. Please review our privacy policy.