Baat bile acid-Coenzyme A: amino acid N-acyltransferase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Baatprovided by MGI
Official Full Name: bile acid-Coenzyme A: amino acid N-acyltransferaseprovided by MGI
Primary source: MGI:MGI:106642
See related: Ensembl:ENSMUSG00000039653 AllianceGenome:MGI:106642
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: BAT
Summary: Enables N-acyltransferase activity. Acts upstream of or within bile acid metabolic process. Located in cytosol. Human ortholog(s) of this gene implicated in disease of metabolism. Orthologous to human BAAT (bile acid-CoA:amino acid N-acyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in liver adult (RPKM 17.8), liver E18 (RPKM 3.3) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 4 B1; 4 26.51 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (49489416..49507915, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (49489416..49507915, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

cytosolic BACAT enzyme may play important roles in protection against toxicity by accumulation of unconjugated bile acids and non-esterified very long-chain fatty acids
Title: The human bile acid-CoA:amino acid N-acyltransferase functions in the conjugation of fatty acids to glycine.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

AI158864 (e-PCR)
- UniSTS:159241

AI118337 (e-PCR)
- UniSTS:178998

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables N-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acyltransferase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables carboxylic ester hydrolase activity	IEA Inferred from Electronic Annotation more info
enables choloyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables fatty acyl-CoA hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glycine N-choloyltransferase activity	IEA Inferred from Electronic Annotation more info
enables glycine N-choloyltransferase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty acyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables medium-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables very long-chain fatty acyl-CoA hydrolase activity	IEA Inferred from Electronic Annotation more info
enables very long-chain fatty acyl-CoA hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acyl-CoA metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acyl-CoA metabolic process	IEA Inferred from Electronic Annotation more info
involved_in acyl-CoA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEA Inferred from Electronic Annotation more info
involved_in bile acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in bile acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in bile acid conjugation	IEA Inferred from Electronic Annotation more info
involved_in bile acid conjugation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bile acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in liver development	IEA Inferred from Electronic Annotation more info
involved_in taurine metabolic process	IEA Inferred from Electronic Annotation more info
involved_in taurine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in peroxisome	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisome	IEA Inferred from Electronic Annotation more info
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: bile acid-CoA:amino acid N-acyltransferase

Names: BACAT; bile acid-CoA thioesterase; bile acid-Coenzyme A dehydrogenase: amino acid n-acyltransferase; choloyl-CoA hydrolase; glycine N-choloyltransferase; long-chain fatty-acyl-CoA hydrolase; taurine N-acyltransferase

NP_031545.2

EC 2.3.1.65

EC 3.1.2.2

EC 3.1.2.27

XP_006537628.1

EC 2.3.1.65

EC 3.1.2.2

EC 3.1.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_007519.3 → NP_031545.2 bile acid-CoA:amino acid N-acyltransferase

See identical proteins and their annotated locations for NP_031545.2

Status: VALIDATED

Source sequence(s)

AA255212, AK017923, BB800891, BY080271, CB947692, U95215

Consensus CDS

CCDS18173.1

UniProtKB/Swiss-Prot

A2AKK7, O08833, Q8C1I3, Q91X34

Related

ENSMUSP00000041983.3, ENSMUST00000043056.9

Conserved Domains (2) summary

pfam08840
Location:207 → 414

BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal

pfam04775
Location:14 → 140

Bile_Hydr_Trans; Acyl-CoA thioester hydrolase/BAAT N-terminal region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

49489416..49507915 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006537565.4 → XP_006537628.1 bile acid-CoA:amino acid N-acyltransferase isoform X1

Conserved Domains (1) summary

pfam08840
Location:34 → 241

BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal