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    Ndst2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 [ Mus musculus (house mouse) ]

    Gene ID: 17423, updated on 9-Dec-2024

    Summary

    Official Symbol
    Ndst2provided by MGI
    Official Full Name
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2provided by MGI
    Primary source
    MGI:MGI:97040
    See related
    Ensembl:ENSMUSG00000039308 AllianceGenome:MGI:97040
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mndns; NDST-2
    Summary
    Enables N-acetylglucosamine deacetylase activity; [heparan sulfate]-glucosamine N-sulfotransferase activity; and heparan sulfate N-deacetylase activity. Involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Acts upstream of or within mast cell mediated immunity and regulation of angiotensin levels in blood. Located in Golgi apparatus. Is expressed in several structures, including brain; genitourinary system; liver; lung; and spleen. Orthologous to human NDST2 (N-deacetylase and N-sulfotransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 14.4), limb E14.5 (RPKM 12.4) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Ndst2 in Genome Data Viewer
    Location:
    14 A3; 14 11.53 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (20773798..20784638, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (20723730..20734570, complement)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6230400D17 gene Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 1 Neighboring gene zinc finger SWIM-type containing 8 Neighboring gene calcium/calmodulin-dependent protein kinase II gamma Neighboring gene STARR-seq mESC enhancer starr_36118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:21604587-21604774 Neighboring gene predicted gene, 30108

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC124373, MGC124374

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in Golgi apparatus  
    is_active_in Golgi apparatus PubMed 
    located_in Golgi apparatus PubMed 
    located_in Golgi membrane  

    General protein information

    Preferred Names
    bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2
    Names
    N-HSST 2
    N-heparan sulfate sulfotransferase 2
    [Heparan sulfate]-glucosamine N-sulfotransferase
    glucosaminyl N-deacetylase/N-sulfotransferase 2
    glucosaminyl N-deacetylase/N-sulphotransferase 2
    heparan N-sulfotransferase 2
    heparan glucosaminyl N-deacetylase/N-sulfotransferase 2
    heparan sulfate N-deacetylase/N-sulfotransferase 2
    mastocytoma N-deacetylase/N-sulfotransferase
    NP_034941.2
    XP_030103542.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010811.2NP_034941.2  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

      See identical proteins and their annotated locations for NP_034941.2

      Status: VALIDATED

      Source sequence(s)
      AC121599, AI173867, AK150100, BC110480
      Consensus CDS
      CCDS26854.1
      UniProtKB/Swiss-Prot
      P52850, Q3UDF4, Q549P5
      Related
      ENSMUSP00000153036.2, ENSMUST00000223679.2
      Conserved Domains (2) summary
      pfam00685
      Location:603852
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:26514
      HSNSD; heparan sulfate-N-deacetylase

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      20773798..20784638 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030247682.1XP_030103542.1  bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2 isoform X1

      Conserved Domains (2) summary
      pfam00685
      Location:603797
      Sulfotransfer_1; Sulfotransferase domain
      pfam12062
      Location:26514
      HSNSD; heparan sulfate-N-deacetylase

    RNA

    1. XR_003950827.2 RNA Sequence

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