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    MCO10 Mco10p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 1466480, updated on 4-Jan-2025

    Summary

    Official Symbol
    MCO10
    Official Full Name
    Mco10p
    Primary source
    SGD:S000028526
    Locus tag
    YOR020W-A
    See related
    AllianceGenome:SGD:S000028526; FungiDB:YOR020W-A; VEuPathDB:YOR020W-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Acts upstream of or within calcium ion homeostasis. Located in mitochondrion. Part of proton-transporting ATP synthase complex. [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See MCO10 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (371685..371957)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Hsp10p Neighboring gene protein-arginine N-methyltransferase SFM1 Neighboring gene putative carboxylic ester hydrolase

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by SGD

    Component Evidence Code Pubs
    located_in membrane  
    located_in mitochondrial membrane  
    located_in mitochondrion PubMed 
    located_in mitochondrion  
    part_of proton-transporting ATP synthase complex PubMed 

    General protein information

    Preferred Names
    Mco10p
    NP_878168.1
    • Subunit l of the mitochondrial F1F0 ATP synthase; F1F0 ATP synthase is a large, evolutionarily conserved enzyme complex required for ATP synthesis; more abundant in the ATP synthase monomer; involved in the calcium-induced permeability transition and calcium homeostasis; does not impact ATP synthase activity and stability; N-terminal region has sequence similarity to Atp19p; conserved in A. gossypii; detected in highly purified mitochondria in high-throughput studies

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      371685..371957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184536.1 → NP_878168.1  TPA: Mco10p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_878168.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W287, Q3E824
      UniProtKB/TrEMBL
      A6ZNM5, B3LJ75, C7GLF1, C8ZHY3, G2WMQ2, N1P2X7
      Conserved Domains (1) summary
      pfam11022
      Location:4 → 82
      DUF2611; Protein of unknown function (DUF2611)
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