YSC84 Ysc84p [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: YSC84
Official Full Name: Ysc84p
Primary source: SGD:S000001058
Locus tag: YHR016C
See related: AllianceGenome:SGD:S000001058; FungiDB:YHR016C; VEuPathDB:YHR016C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: LSB4
Summary: Enables actin filament binding activity. Involved in actin cortical patch localization; actin filament bundle assembly; and endocytosis. Located in actin cortical patch. Orthologous to human SH3YL1 (SH3 and SYLF domain containing 1). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

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Distinct actin and lipid binding sites in Ysc84 are required during early stages of yeast endocytosis.
Title: Distinct Actin and Lipid Binding Sites in Ysc84 Are Required during Early Stages of Yeast Endocytosis.
Our analysis suggests a novel role for the SH3 domains of Lsb3p and Lsb4p as hubs that recruit and assemble several endocytic complexes.
Title: Bayesian modeling of the yeast SH3 domain interactome predicts spatiotemporal dynamics of endocytosis proteins.
polyproline region of Las17 and Ysc84 can promote actin polymerization
Title: The WASP homologue Las17 activates the novel actin-regulatory activity of Ysc84 to promote endocytosis in yeast.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in actin cortical patch localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin cortical patch localization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in actin cortical patch localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament bundle assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in endocytosis	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in actin cortical patch	IBA Inferred from Biological aspect of Ancestor more info
located_in actin cortical patch	IDA Inferred from Direct Assay more info	PubMed
located_in actin cortical patch	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed

NP_011880.1

Actin-binding protein; involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p; YSC84 has a paralog, LSB3, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain