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    cwf19 protein Cwf19 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543189, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cwf19
    Official Full Name
    protein Cwf19
    Primary source
    PomBase:SPAC30D11.09
    Locus tag
    SPOM_SPAC30D11.09
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See cwf19 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (1101685..1103807, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene DNA recombination mediator Rad52 (previously Rad22) Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Lsd1/2 complex PHD finger domain-containing protein Phf2 Neighboring gene ncRNA Neighboring gene DNA endonuclease III

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. All-atom simulations disentangle the functional dynamics underlying gene maturation in the intron lariat spliceosome. Casalino L, et al. Proc Natl Acad Sci U S A, 2018 Jun 26. PMID 29891649, Free PMC Article
    2. Splicing of branchpoint-distant exons is promoted by Cactin, Tls1 and the ubiquitin-fold-activated Sde2. Anil AT, et al. Nucleic Acids Res, 2022 Sep 23. PMID 36095128, Free PMC Article
    3. Structure of a yeast spliceosome at 3.6-angstrom resolution. Yan C, et al. Science, 2015 Sep 11. PMID 26292707
    4. Identification of proteins associated with splicing factors Ntr1, Ntr2, Brr2 and Gpl1 in the fission yeast Schizosaccharomyces pombe. Cipakova I, et al. Cell Cycle, 2019 Jul. PMID 31219728, Free PMC Article
    5. A systematic genetic screen identifies new factors influencing centromeric heterochromatin integrity in fission yeast. Bayne EH, et al. Genome Biol, 2014. PMID 25274039, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The intron lariat spliceosome essential dynamics unveils the critical participation of the Cwf19 protein in displacing the intron lariat/U2 branch helix.
      Title: All-atom simulations disentangle the functional dynamics underlying gene maturation in the intron lariat spliceosome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA cis splicing, via spliceosome EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in mRNA cis splicing, via spliceosome IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of post-mRNA release spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of post-mRNA release spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    protein Cwf19

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1101685..1103807 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018604.3 → NP_593208.1  protein Cwf19 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593208.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09909
      Conserved Domains (3) summary
      pfam04677
      Location:399 → 523
      CwfJ_C_1; Protein similar to CwfJ C-terminus 1
      pfam04676
      Location:532 → 634
      CwfJ_C_2; Protein similar to CwfJ C-terminus 2
      cl40444
      Location:162 → 215
      DBD_XPA-like; DNA-binding domain found in DNA repair protein complementing XP-A cells (XPA), yeast DNA repair protein RAD14 and similar proteins
    Nucleotide Protein
    Heading Accession and Version

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