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    fkh1 FKBP-type peptidyl-prolyl cis-trans isomerase Fkh1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541195, updated on 18-Sep-2024

    Summary

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    Official Symbol
    fkh1
    Official Full Name
    FKBP-type peptidyl-prolyl cis-trans isomerase Fkh1
    Primary source
    PomBase:SPBC839.17c
    Locus tag
    SPOM_SPBC839.17C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See fkh1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003423.3 (631697..632677, complement)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene translation elongation factor EF-1 alpha Ef1a-c Neighboring gene C1-5,6,7,8-tetrahydrofolate (THF) synthase, trifunctional enzyme Thf1 Neighboring gene gfo/idh/mocA family oxidoreductase Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapamycin blocks sexual development in fission yeast through inhibition of the cellular function of an FKBP12 homolog. Weisman R, et al. J Biol Chem, 2001 Jul 6. PMID 11335722
    2. Opposite effects of tor1 and tor2 on nitrogen starvation responses in fission yeast. Weisman R, et al. Genetics, 2007 Mar. PMID 17179073, Free PMC Article
    3. The cytosolic form of aspartate aminotransferase is required for full activation of TOR complex 1 in fission yeast. Reidman S, et al. J Biol Chem, 2019 Nov 29. PMID 31641022, Free PMC Article
    4. Regulation of leucine uptake by tor1+ in Schizosaccharomyces pombe is sensitive to rapamycin. Weisman R, et al. Genetics, 2005 Feb. PMID 15466417, Free PMC Article
    5. Fission yeast TOR signaling is essential for the down-regulation of a hyperactivated stress-response MAP kinase under salt stress. Ishiguro J, et al. Mol Genet Genomics, 2013 Feb. PMID 23271606

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables peptidyl-prolyl cis-trans isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in conjugation with cellular fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    FKBP-type peptidyl-prolyl cis-trans isomerase Fkh1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      631697..632677 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021163.3 → NP_595257.1  FKBP-type peptidyl-prolyl cis-trans isomerase Fkh1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595257.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O42993
      Conserved Domains (2) summary
      COG0545
      Location:2 → 108
      FkpA; FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones]
      pfam00254
      Location:13 → 105
      FKBP_C; FKBP-type peptidyl-prolyl cis-trans isomerase
    Nucleotide Protein
    Heading Accession and Version

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