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    tpz1 telomere-protecting protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542414, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tpz1
    Official Full Name
    telomere-protecting protein
    Primary source
    PomBase:SPAC6F6.16c
    Locus tag
    SPOM_SPAC6F6.16C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    mug169; SPAC6F6.18c
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    Genomic context

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    See tpz1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003424.3 (2762475..2765904, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene GTPase Ypt5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene telomere length regulator Rif1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tpz1(TPP1) prevents telomerase activation and protects telomeres by modulating the Stn1-Ten1 complex in fission yeast. Mennie AK, et al. Commun Biol, 2019. PMID 31396577, Free PMC Article
    2. Finding the end: recruitment of telomerase to telomeres. Nandakumar J, et al. Nat Rev Mol Cell Biol, 2013 Feb. PMID 23299958, Free PMC Article
    3. DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe. Nandakumar J, et al. Nucleic Acids Res, 2012 Jan. PMID 21911358, Free PMC Article
    4. Structural Basis for Shelterin Bridge Assembly. Kim JK, et al. Mol Cell, 2017 Nov 16. PMID 29149597, Free PMC Article
    5. Spatial Organization and Molecular Interactions of the Schizosaccharomyces pombe Ccq1-Tpz1-Poz1 Shelterin Complex. Scott H, et al. J Mol Biol, 2017 Sep 15. PMID 28807855, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.
      Title: The cooperative assembly of shelterin bridge provides a kinetic gateway that controls telomere length homeostasis.
    2. A novel dual-function regulatory motif within Tpz1 unctions redundantly with Lys242 SUMOylation to promote telomere association of the Stn1-Ten1 complex, protecting telomeres, and counteracting TEL-patch-dependent telomerase activation to limit telomere extension.
      Title: Tpz1(TPP1) prevents telomerase activation and protects telomeres by modulating the Stn1-Ten1 complex in fission yeast.
    3. Together, these data provide a first glimpse into the architectural design of the Ccq1-Tpz1-Poz1 complex and reveals unique interactions that are important in maintaining the Schizosaccharomyces pombe telomere in a non-extendible state.
      Title: Spatial Organization and Molecular Interactions of the Schizosaccharomyces pombe Ccq1-Tpz1-Poz1 Shelterin Complex.
    4. The conservation between fission yeast Tpz1-Pot1 and human TPP1-POT1 interactions resulted in mapping a human melanoma-associated POT1 mutation (A532P) to the TPP1-POT1 interface.
      Title: Dissecting Fission Yeast Shelterin Interactions via MICro-MS Links Disruption of Shelterin Bridge to Tumorigenesis.
    5. Tpz1-Ccq1 interaction is required for Ccq1 Thr93 phosphorylation and telomerase recruitment.
      Title: Tpz1-Ccq1 and Tpz1-Poz1 interactions within fission yeast shelterin modulate Ccq1 Thr93 phosphorylation and telomerase recruitment.
    6. SUMO inhibits telomerase through stimulation of Stn1/Ten1 action by Tpz1.
      Title: Tpz1TPP1 SUMOylation reveals evolutionary conservation of SUMO-dependent Stn1 telomere association.
    7. fission yeast shelterin (shelterin subunits Poz1, Rap1 and Taz1 )maintains telomere length homeostasis by coordinating the differential arrival of leading (Polepsilon) and lagging (Polalpha) strand DNA polymerases at telomeres to modulate Rad3(ATR) association
      Title: Fission yeast shelterin regulates DNA polymerases and Rad3(ATR) kinase to limit telomere extension.
    8. Tpz1 (the ortholog of human TPP1)-mediated complete linkage within the shelterin complex, bridging telomeric dsDNA to ssDNA, controls the telomerase-nonextendible state
      Title: Tpz1 controls a telomerase-nonextendible telomeric state and coordinates switching to an extendible state via Ccq1.
    9. Tpz1 forms a complex with Pot1; Tpz1 binds to Ccq1 & Poz1 which protect telomeres redundantly & regulate telomerase in positive & negative manners; thus, Pot1-Tpz1 complex accomplishes its functions by recruiting effector molecules Ccq1 & Poz1
      Title: Fission yeast Pot1-Tpp1 protects telomeres and regulates telomere length.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables telomeric DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein localization to chromosome, telomeric region IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere capping IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance via telomerase IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere-telomerase complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in chromosome, telomeric repeat region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of shelterin complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of shelterin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of telomere cap complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    telomere-protecting protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      2762475..2765904 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001356076.2 → NP_001342857.1  telomere-protecting protein [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      B3A004, O14246
      Conserved Domains (1) summary
      pfam10341
      Location:9 → 105
      TPP1; Shelterin complex subunit, TPP1/ACD
    Nucleotide Protein
    Heading Accession and Version

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