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    TAF1 histone acetyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853191, updated on 4-Jan-2025

    Summary

    Official Symbol
    TAF1
    Official Full Name
    histone acetyltransferase
    Primary source
    SGD:S000003506
    Locus tag
    YGR274C
    See related
    AllianceGenome:SGD:S000003506; FungiDB:YGR274C; VEuPathDB:YGR274C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KAT4; TAF130; TAF145
    Summary
    Enables several functions, including TBP-class protein binding activity; chromatin binding activity; and histone acetyltransferase activity. Involved in RNA polymerase II preinitiation complex assembly. Located in cytosol and nucleus. Part of transcription factor TFIID complex. Human ortholog(s) of this gene implicated in X-linked dystonia-parkinsonism and syndromic X-linked intellectual disability. Orthologous to several human genes including TAF1L (TATA-box binding protein associated factor 1 like). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See TAF1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (1039895..1043095, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Efg1p Neighboring gene uncharacterized protein Neighboring gene Rtt102p Neighboring gene Rnh70p

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Items 1 - 25 of 30
    Function Evidence Code Pubs
    enables RNA polymerase II general transcription initiation factor activity  
    enables RNA polymerase II general transcription initiation factor activity  
    enables TBP-class protein binding  
    enables TBP-class protein binding PubMed 
    enables TBP-class protein binding  
    enables acyltransferase activity  
    enables chromatin binding PubMed 
    enables histone H2AK5 acetyltransferase activity  
    enables histone H2AK9 acetyltransferase activity  
    enables histone H2BK12 acetyltransferase activity  
    enables histone H2BK5 acetyltransferase activity  
    enables histone H3K122 acetyltransferase activity  
    enables histone H3K14 acetyltransferase activity  
    enables histone H3K18 acetyltransferase activity  
    enables histone H3K23 acetyltransferase activity  
    enables histone H3K27 acetyltransferase activity  
    enables histone H3K36 acetyltransferase activity  
    enables histone H3K4 acetyltransferase activity  
    enables histone H3K56 acetyltransferase activity  
    enables histone H3K9 acetyltransferase activity  
    enables histone H4K12 acetyltransferase activity  
    enables histone H4K16 acetyltransferase activity  
    enables histone H4K5 acetyltransferase activity  
    enables histone H4K8 acetyltransferase activity  
    enables histone acetyltransferase activity PubMed 
    enables histone acetyltransferase activity  
    enables molecular adaptor activity PubMed 
    enables molecular adaptor activity PubMed 
    enables peptide-lysine-N-acetyltransferase activity  
    enables zinc ion binding PubMed 
    Items 1 - 25 of 30
    Component Evidence Code Pubs
    located_in cytosol PubMed 
    located_in nucleus PubMed 
    located_in nucleus  
    part_of transcription factor TFIID complex  
    part_of transcription factor TFIID complex PubMed 
    part_of transcription factor TFIID complex  

    General protein information

    Preferred Names
    histone acetyltransferase
    NP_011790.1
    • TFIID subunit, involved in RNA pol II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression; relocalizes to the cytosol in response to hypoxia

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      1039895..1043095 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181403.2 → NP_011790.1  TPA: histone acetyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011790.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV51, P46677
      UniProtKB/TrEMBL
      C7GNG1, C8Z9G7, N1P6A1
      Conserved Domains (1) summary
      COG5179
      Location:21 → 1066
      TAF1; Transcription initiation factor TFIID, subunit TAF1 [Transcription]
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