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    mak3 phosphorelay sensor kinase Mak3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2539117, updated on 18-Sep-2024

    Summary

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    Official Symbol
    mak3
    Official Full Name
    phosphorelay sensor kinase Mak3
    Primary source
    PomBase:SPCC74.06
    Locus tag
    SPOM_SPCC74.06
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    phk2
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    Genomic context

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    See mak3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_003421.2 (1940315..1947736)

    Chromosome III - NC_003421.2Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene gamma-aminobutyric acid/polyamine transporter Neighboring gene ncRNA Neighboring gene 60S ribosomal protein eL27 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene beta-glucosidase Adg3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003421.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic analysis of the His-to-Asp phosphorelay implicated in mitotic cell cycle control: involvement of histidine-kinase genes of Schizosaccharomyces pombe. Aoyama K, et al. Biosci Biotechnol Biochem, 2001 Oct. PMID 11758939
    2. Stress sensitivity of a fission yeast strain lacking histidine kinases is rescued by the ectopic expression of Chk1 from Candida albicans. Maksimov V, et al. Curr Genet, 2017 May. PMID 27613427, Free PMC Article
    3. Two-component mediated peroxide sensing and signal transduction in fission yeast. Quinn J, et al. Antioxid Redox Signal, 2011 Jul 1. PMID 20919928
    4. Peroxide sensors for the fission yeast stress-activated mitogen-activated protein kinase pathway. Buck V, et al. Mol Biol Cell, 2001 Feb. PMID 11179424, Free PMC Article
    5. Functional characterization of the phosphorelay protein Mpr1p from Schizosaccharomyces pombe. Tan H, et al. FEMS Yeast Res, 2007 Sep. PMID 17559414

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate distinct functions for the three histidine kinases; Mak1 alone or Mak2 and Mak3 together were sufficient for the repression of the meiotic cycle when nutrients were available.
      Title: Stress sensitivity of a fission yeast strain lacking histidine kinases is rescued by the ectopic expression of Chk1 from Candida albicans.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphorelay sensor kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables phosphorelay sensor kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphorelay signal transduction system IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of p38MAPK cascade IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of p38MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of p38MAPK cascade IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol HDA PubMed 
    part_of protein histidine kinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphorelay sensor kinase Mak3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003421.2 Reference assembly

      Range
      1940315..1947736
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001023370.3 → NP_588379.1  phosphorelay sensor kinase Mak3 [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O74539
      Conserved Domains (9) summary
      smart00387
      Location:1898 → 2002
      HATPase_c; Histidine kinase-like ATPases
      smart00388
      Location:1786 → 1850
      HisKA; His Kinase A (phosphoacceptor) domain
      COG0515
      Location:49 → 306
      SPS1; Serine/threonine protein kinase [Signal transduction mechanisms]
      COG2203
      Location:1474 → 1636
      FhlA; GAF domain [Signal transduction mechanisms]
      COG3899
      Location:388 → 1397
      COG3899; Predicted ATPase [General function prediction only]
      cd00130
      Location:1702 → 1769
      PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
      cd00156
      Location:2213 → 2333
      REC; Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; ...
      pfam00989
      Location:1658 → 1769
      PAS; PAS fold
      cl21453
      Location:122 → 293
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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