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    tnr3 thiamine diphosphokinase Tnr3/ Nudix hydrolase fusion protein [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2543032, updated on 18-Sep-2024

    Summary

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    Official Symbol
    tnr3
    Official Full Name
    thiamine diphosphokinase Tnr3/ Nudix hydrolase fusion protein
    Primary source
    PomBase:SPAC6F12.05c
    Locus tag
    SPOM_SPAC6F12.05C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See tnr3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (1316981..1318978, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene COPI-coated vesicle-associated protein Neighboring gene ncRNA Neighboring gene Rho GDP dissociation inhibitor Rdi1 Neighboring gene TOM complex subunit Tom20 Neighboring gene exocyst complex subunit Exo84

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Schizosaccharomyces pombe thiamine pyrophosphokinase is encoded by gene tnr3 and is a regulator of thiamine metabolism, phosphate metabolism, mating, and growth. Fankhauser H, et al. J Biol Chem, 1995 Nov 24. PMID 7499352
    2. Isolation and characterization of regulatory mutants from Schizosaccharomyces pombe involved in thiamine-regulated gene expression. Schweingruber AM, et al. Genetics, 1992 Mar. PMID 1551569, Free PMC Article
    3. A cross-kingdom Nudix enzyme that pre-empts damage in thiamin metabolism. Goyer A, et al. Biochem J, 2013 Sep 15. PMID 23834287
    4. Genetic screen for suppression of transcriptional interference reveals fission yeast 14-3-3 protein Rad24 as an antagonist of precocious Pol2 transcription termination. Garg A, et al. Nucleic Acids Res, 2022 Jan 25. PMID 34967420, Free PMC Article
    5. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables 8-oxo-dGDP phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine diphosphokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine diphosphokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thiamine diphosphokinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in thiamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thiamine diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thiamine salvage EXP
    Inferred from Experiment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm HDA PubMed 
    is_active_in cytosol HDA PubMed 

    General protein information

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    Preferred Names
    thiamine diphosphokinase Tnr3/ Nudix hydrolase fusion protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1316981..1318978 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018721.3 → NP_593291.1  thiamine diphosphokinase Tnr3/ Nudix hydrolase fusion protein [Schizosaccharomyces pombe]

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P41888
      Conserved Domains (4) summary
      cd07995
      Location:354 → 562
      TPK; Thiamine pyrophosphokinase
      cd03676
      Location:103 → 282
      Nudix_hydrolase_3; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belong to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
      TIGR01378
      Location:355 → 565
      thi_PPkinase; thiamine pyrophosphokinase
      pfam15916
      Location:33 → 131
      DUF4743; Domain of unknown function (DUF4743)
    Nucleotide Protein
    Heading Accession and Version

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