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    hri1 eIF2 alpha kinase Hri1 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2541728, updated on 14-Nov-2024

    Summary

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    Official Symbol
    hri1
    Official Full Name
    eIF2 alpha kinase Hri1
    Primary source
    PomBase:SPAC20G4.03c
    Locus tag
    SPOM_SPAC20G4.03C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See hri1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_003424.3 (4818012..4820651, complement)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene CCR4-Not complex subunit Caf16 Neighboring gene ncRNA Neighboring gene formin Fus1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene checkpoint clamp complex protein Hus1 Neighboring gene adenylyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New roles of the fission yeast eIF2α kinases Hri1 and Gcn2 in response to nutritional stress. Martín R, et al. J Cell Sci, 2013 Jul 15. PMID 23687372
    2. Phosphorylation of eukaryotic initiation factor 2 by heme-regulated inhibitor kinase-related protein kinases in Schizosaccharomyces pombe is important for fesistance to environmental stresses. Zhan K, et al. Mol Cell Biol, 2002 Oct. PMID 12242291, Free PMC Article
    3. Role of mitogen-activated protein kinase Sty1 in regulation of eukaryotic initiation factor 2alpha kinases in response to environmental stress in Schizosaccharomyces pombe. Berlanga JJ, et al. Eukaryot Cell, 2010 Jan. PMID 19880757, Free PMC Article
    4. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Roguev A, et al. Science, 2008 Oct 17. PMID 18818364, Free PMC Article
    5. A Proteome-wide Fission Yeast Interactome Reveals Network Evolution Principles from Yeasts to Human. Vo TV, et al. Cell, 2016 Jan 14. PMID 26771498, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the results indicate for the first time that Hri1 is activated by both nitrogen starvation and stationary phase entry stresses, whereas Hri2 is activated in response to glucose limitation.
      Title: New roles of the fission yeast eIF2α kinases Hri1 and Gcn2 in response to nutritional stress.
    2. These findings point to a regulatory coordination between the Sty1 MAPK and Hri1/Hri2 eIF2alpha kinase pathways for a particular range of stress responses.
      Title: Role of mitogen-activated protein kinase Sty1 in regulation of eukaryotic initiation factor 2alpha kinases in response to environmental stress in Schizosaccharomyces pombe.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ATP binding ISM
    Inferred from Sequence Model
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cytoplasmic translational initiation in response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cytoplasmic translational initiation in response to stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signaling IC
    Inferred by Curator
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eIF2 alpha kinase Hri1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      4818012..4820651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001020166.3 → NP_594738.1  eIF2 alpha kinase Hri1 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_594738.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      O13889
      Conserved Domains (2) summary
      cd13996
      Location:217 → 661
      STKc_EIF2AK; Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase
      pfam00069
      Location:224 → 658
      Pkinase; Protein kinase domain
    Nucleotide Protein
    Heading Accession and Version

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