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    LEU2 3-isopropylmalate dehydrogenase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850342, updated on 4-Jan-2025

    Summary

    Official Symbol
    LEU2
    Official Full Name
    3-isopropylmalate dehydrogenase
    Primary source
    SGD:S000000523
    Locus tag
    YCL018W
    See related
    AllianceGenome:SGD:S000000523; FungiDB:YCL018W; VEuPathDB:YCL018W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 3-isopropylmalate dehydrogenase activity. Involved in L-leucine biosynthetic process and glyoxylate cycle. Located in cytosol. [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

    See LEU2 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (91324..92418)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene gag protein Neighboring gene gag-pol fusion protein Neighboring gene tRNA-Leu Neighboring gene cysteine desulfurase Neighboring gene Dcc1p

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-isopropylmalate dehydrogenase activity  
    enables 3-isopropylmalate dehydrogenase activity PubMed 
    enables 3-isopropylmalate dehydrogenase activity  
    enables 3-isopropylmalate dehydrogenase activity PubMed 
    enables NAD binding  
    enables magnesium ion binding  
    enables metal ion binding  
    enables oxidoreductase activity  
    Process Evidence Code Pubs
    involved_in L-leucine biosynthetic process  
    involved_in L-leucine biosynthetic process  
    involved_in L-leucine biosynthetic process PubMed 
    involved_in glyoxylate cycle PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol PubMed 

    General protein information

    Preferred Names
    3-isopropylmalate dehydrogenase
    NP_009911.2
    • Beta-isopropylmalate dehydrogenase (IMDH); catalyzes the third step in the leucine biosynthesis pathway; can additionally catalyze the conversion of beta-ethylmalate into alpha-ketovalerate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      91324..92418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178665.1 → NP_009911.2  TPA: 3-isopropylmalate dehydrogenase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009911.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQZ6, P04173
      UniProtKB/TrEMBL
      A6ZTG8, B5VET6, C7GQK2, C8Z469, G2WA04
      Conserved Domains (1) summary
      TIGR00169
      Location:6 → 359
      leuB; 3-isopropylmalate dehydrogenase
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