Mob2 MOB kinase activator 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mob2provided by MGI
Official Full Name: MOB kinase activator 2provided by MGI
Primary source: MGI:MGI:1919891
See related: Ensembl:ENSMUSG00000025147 AllianceGenome:MGI:1919891
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Mmh; 1110017M21Rik; 2700078K21Rik
Summary: Predicted to enable protein kinase activator activity. Acts upstream of or within actin cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Located in cytoplasm and neuron projection terminus. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and integumental system. Orthologous to human MOB2 (MOB kinase activator 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 13.7), colon adult (RPKM 11.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 F5; 7 87.5 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (141562254..141614796, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (142008517..142061059, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study identified Mob2 protein which plays a significant role in promoting neurite formation in Neuro2A (N2A) cells
Title: The promotion of neurite formation in Neuro2A cells by mouse Mob2 protein.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:235815

CA25.5 (e-PCR), detects polymorphism
- UniSTS:141202

RH129366 (e-PCR)
- UniSTS:212673

AI256456 (e-PCR)
- UniSTS:159721

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in neuron projection terminus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: MOB kinase activator 2

Names: Mps one binder kinase activator-like 2; mob2 homolog; ovary-specific MOB-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347560.1 → NP_001334489.1 MOB kinase activator 2 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.

Source sequence(s)

AL603836

Consensus CDS

CCDS85460.1

UniProtKB/TrEMBL

Q3TYF8

Related

ENSMUSP00000147608.2, ENSMUST00000211206.2

Conserved Domains (1) summary

pfam03637
Location:5 → 115

Mob1_phocein; Mob1/phocein family
NM_001357705.1 → NP_001344634.1 MOB kinase activator 2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate, frame-shifting splice site in the 3' coding region compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.

Source sequence(s)

AL603836

Conserved Domains (1) summary

pfam03637
Location:32 → 140

Mob1_phocein; Mob1/phocein family
NM_001374635.1 → NP_001361564.1 MOB kinase activator 2 isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) encodes the longest isoform (4).

Source sequence(s)

AL603836

Consensus CDS

CCDS90353.1

UniProtKB/TrEMBL

A0A1B0GR18

Related

ENSMUSP00000147340.2, ENSMUST00000209732.2

Conserved Domains (1) summary

pfam03637
Location:63 → 231

Mob1_phocein; Mob1/phocein family
NM_001382351.1 → NP_001369280.1 MOB kinase activator 2 isoform 2

Status: VALIDATED

Source sequence(s)

AL603836

UniProtKB/TrEMBL

Q3TYF8

Related

ENSMUSP00000147643.2, ENSMUST00000211000.2

Conserved Domains (1) summary

pfam03637
Location:5 → 115

Mob1_phocein; Mob1/phocein family
NM_028308.2 → NP_082584.1 MOB kinase activator 2 isoform 1

See identical proteins and their annotated locations for NP_082584.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the isoform 1.

Source sequence(s)

AL603836

Consensus CDS

CCDS40190.1

UniProtKB/Swiss-Prot

Q3UXL5, Q8VI63, Q9CZJ5

Related

ENSMUSP00000081455.3, ENSMUST00000084418.4

Conserved Domains (1) summary

pfam03637
Location:32 → 200

Mob1_phocein; Mob1/phocein family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000073.7 Reference GRCm39 C57BL/6J

Range

141562254..141614796 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036152537.1 → XP_036008430.1 MOB kinase activator 2 isoform X1

UniProtKB/TrEMBL

A0A1B0GR18

Conserved Domains (1) summary

pfam03637
Location:63 → 231

Mob1_phocein; Mob1/phocein family
XM_036152538.1 → XP_036008431.1 MOB kinase activator 2 isoform X3

UniProtKB/TrEMBL

Q3TYF8

Conserved Domains (1) summary

pfam03637
Location:5 → 115

Mob1_phocein; Mob1/phocein family
XM_011241972.4 → XP_011240274.1 MOB kinase activator 2 isoform X2

Conserved Domains (1) summary

pfam03637
Location:63 → 171

Mob1_phocein; Mob1/phocein family