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    Masp2 MBL associated serine protease 2 [ Mus musculus (house mouse) ]

    Gene ID: 17175, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Masp2provided by MGI
    Official Full Name
    MBL associated serine protease 2provided by MGI
    Primary source
    MGI:MGI:1330832
    See related
    Ensembl:ENSMUSG00000028979 AllianceGenome:MGI:1330832
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MAp19; MASP-2
    Summary
    Predicted to enable several functions, including calcium-dependent protein binding activity; complement component C4b binding activity; and serine-type endopeptidase activity. Predicted to be involved in complement activation, lectin pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including brain and liver. Orthologous to human MASP2 (MBL associated serine protease 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 80.9), liver E18 (RPKM 34.9) and 18 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Masp2 in Genome Data Viewer
    Location:
    4 E2; 4 78.76 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (148679079..148699939)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (148594622..148615499)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1668 Neighboring gene exosome component 10 Neighboring gene spermidine synthase Neighboring gene TAR DNA binding protein Neighboring gene STARR-positive B cell enhancer ABC_E4729 Neighboring gene STARR-seq mESC enhancer starr_12080 Neighboring gene STARR-seq mESC enhancer starr_12082 Neighboring gene predicted gene 572 Neighboring gene STARR-seq mESC enhancer starr_12083 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:148057732-148057915 Neighboring gene predicted gene 13203

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury. Mercurio D, et al. J Neuroinflammation, 2024 May 28. PMID 38807149, Free PMC Article
    2. Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway. Iwaki D, et al. J Immunol, 2006 Dec 15. PMID 17142762
    3. Absence of the Lectin Activation Pathway of Complement Ameliorates Proteinuria-Induced Renal Injury. Alghadban S, et al. Front Immunol, 2019. PMID 31608060, Free PMC Article
    4. Production and purification of recombinants of mouse MASP-2 and sMAP. Iwaki D, et al. J Endotoxin Res, 2005. PMID 15826378
    5. Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1. Orsini F, et al. J Neuroinflammation, 2016 Aug 30. PMID 27577570, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury.
      Title: Inhibition of mannan-binding lectin associated serine protease (MASP)-2 reduces the cognitive deficits in a mouse model of severe traumatic brain injury.
    2. that MASP-2 deficiency can increase susceptibility to adult Herpes simplex virus encephalitis
      Title: Herpes simplex encephalitis in adult patients with MASP-2 deficiency.
    3. It has been shown that key proteins in the lectin arm of this pathway, MASP1, MASP2 and C3, are expressed in the developing cortex and that neuronal migration is impaired in knockout and knockdown mice.
      Title: Developmental activities of the complement pathway in migrating neurons.
    4. MASP-2 has an essential role in the mediation of cerebral ischemia-reperfusion injury.
      Title: Mannan binding lectin-associated serine protease-2 (MASP-2) critically contributes to post-ischemic brain injury independent of MASP-1.
    5. this study shows that MASP-2 contributes to the development of collagen Ab-induced arthritis
      Title: Deconstructing the Lectin Pathway in the Pathogenesis of Experimental Inflammatory Arthritis: Essential Role of the Lectin Ficolin B and Mannose-Binding Protein-Associated Serine Protease 2.
    6. We induced anti-myeloperoxidase vasculitis in mice and showed that neither MASP-2- nor properdin-deficient mice were protected, suggesting that alternative pathway activation does not require properdin or the lectin pathway.
      Title: Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5.
    7. Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4.
      Title: Mannan-binding lectin-associated serine protease 2 is critical for the development of renal ischemia reperfusion injury and mediates tissue injury in the absence of complement C4.
    8. Gene targeting of mouse TDP-43 negatively affects Masp2 expression.
      Title: Gene targeting of mouse Tardbp negatively affects Masp2 expression.
    9. ALI in H5N1-infected mice was caused by excessive complement activation, as demonstrated by deposition of C3, C5b-9, and MBL-C in lung tissue, and by up-regulation of MBL-associated serine protease-2 and the complement receptors C3aR and C5aR.
      Title: Inhibition of complement activation alleviates acute lung injury induced by highly pathogenic avian influenza H5N1 virus infection.
    10. study corroborates the essential function of MASP-2 in the lectin pathway and highlights the importance of mannan-binding lectin-independent lectin pathway activation in the host defense against pneumococci
      Title: The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection.
    Submit: New GeneRIF Correction See all GeneRIFs (15)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables complement component C4b binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables complement component C4b binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables peptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables serine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement activation, lectin pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in complement activation, lectin pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in complement activation, lectin pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    mannan-binding lectin serine protease 2
    Names
    mannan-binding lectin serine peptidase 2
    mannose-binding protein-associated serine protease 2
    NP_001003893.1
    NP_034897.1
    XP_011248504.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001003893.3 → NP_001003893.1  mannan-binding lectin serine protease 2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_001003893.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the longer transcript and it encodes the longer isoform (1).
      Source sequence(s)
      AL606969
      Consensus CDS
      CCDS18941.1
      UniProtKB/Swiss-Prot
      B1ARY2, B1ARY3, Q91WP0, Q9QXA4, Q9QXD2, Q9QXD5, Q9Z338
      Related
      ENSMUSP00000049729.7, ENSMUST00000052060.7
      Conserved Domains (6) summary
      smart00020
      Location:443 → 678
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:19 → 136
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      cd00190
      Location:444 → 681
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam00084
      Location:300 → 361
      Sushi; Sushi repeat (SCR repeat)
      pfam00431
      Location:184 → 293
      CUB; CUB domain
      pfam14670
      Location:152 → 180
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    2. NM_010767.4 → NP_034897.1  mannan-binding lectin serine protease 2 isoform 2 precursor

      See identical proteins and their annotated locations for NP_034897.1

      Status: VALIDATED

      Source sequence(s)
      AL606969
      Consensus CDS
      CCDS18942.1
      UniProtKB/Swiss-Prot
      Q91WP0
      Related
      ENSMUSP00000101326.3, ENSMUST00000105701.9
      Conserved Domains (2) summary
      cd00041
      Location:19 → 136
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam14670
      Location:152 → 180
      FXa_inhibition; Coagulation Factor Xa inhibitory site

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      148679079..148699939
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011250202.4 → XP_011248504.1  mannan-binding lectin serine protease 2 isoform X1

      Conserved Domains (5) summary
      smart00020
      Location:442 → 677
      Tryp_SPc; Trypsin-like serine protease
      cd00041
      Location:18 → 135
      CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
      pfam00084
      Location:299 → 360
      Sushi; Sushi repeat (SCR repeat)
      pfam00431
      Location:183 → 292
      CUB; CUB domain
      pfam14670
      Location:151 → 179
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91WP0.1 GenPept UniProtKB/Swiss-Prot:Q91WP0

    Gene LinkOut

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