Acbd7 acyl-Coenzyme A binding domain containing 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Acbd7provided by MGI
Official Full Name: acyl-Coenzyme A binding domain containing 7provided by MGI
Primary source: MGI:MGI:1925495
See related: Ensembl:ENSMUSG00000026644 AllianceGenome:MGI:1925495
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 9230116B18Rik
Summary: Predicted to enable fatty-acyl-CoA binding activity. Acts upstream of or within several processes, including energy homeostasis; leptin-mediated signaling pathway; and response to food. Orthologous to human ACBD7 (acyl-CoA binding domain containing 7). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in genital fat pad adult (RPKM 14.0), testis adult (RPKM 3.0) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A1; 2 1.87 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (3333850..3342035)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (3332814..3340998)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These data suggest that ACBD7-producing neurons are involved in the hypothalamic control exerted on food intake and energy expenditure by the leptin-melanocortin pathway.
Title: Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice.
This article describes an uncharacterized splice variant of the Acbd7 mRNA. This article also underlines the potential involvement of Acbd7 maturation product as potent anorexigenic neuropeptides.
Title: Involvement of the Acyl-CoA binding domain containing 7 in the control of food intake and energy expenditure in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fatty-acyl-CoA binding	IBA Inferred from Biological aspect of Ancestor more info
enables fatty-acyl-CoA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within energy homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within leptin-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to food	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: acyl-CoA-binding domain-containing protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030063.2 → NP_084339.1 acyl-CoA-binding domain-containing protein 7

See identical proteins and their annotated locations for NP_084339.1

Status: VALIDATED

Source sequence(s)

AK020348, AV497738, BB203468

Consensus CDS

CCDS50485.1

UniProtKB/Swiss-Prot

A2AJG1, Q9D258

Related

ENSMUSP00000110741.2, ENSMUST00000115089.2

Conserved Domains (1) summary

cl00221
Location:3 → 87

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

3333850..3342035

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030252244.2 → XP_030108104.1 acyl-CoA-binding domain-containing protein 7 isoform X1

Conserved Domains (1) summary

cl00221
Location:4 → 87

ACBP; Acyl CoA binding protein (ACBP) binds thiol esters of long fatty acids and coenzyme A in a one-to-one binding mode with high specificity and affinity. Acyl-CoAs are important intermediates in fatty lipid synthesis and fatty acid degradation and play a ...