Gpr6 G protein-coupled receptor 6 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gpr6provided by MGI
Official Full Name: G protein-coupled receptor 6provided by MGI
Primary source: MGI:MGI:2155249
See related: Ensembl:ENSMUSG00000046922 AllianceGenome:MGI:2155249
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gm233
Summary: Enables sphingosine-1-phosphate receptor activity. Acts upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; eye; immune system; male reproductive gland or organ; and nervous system. Orthologous to human GPR6 (G protein-coupled receptor 6). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in cortex adult (RPKM 1.6), CNS E18 (RPKM 1.2) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 B1; 10 22.08 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (40945973..40948286, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (41069977..41072290, complement)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gpr6 deficiency causes an interesting behavioural phenotype in the form of enhanced motor activity combined with reduced abnormal involuntary movements.
Title: G-protein coupled receptor 6 deficiency alters striatal dopamine and cAMP concentrations and reduces dyskinesia in a mouse model of Parkinson's disease.
C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-beta neurotoxicity
Title: C1q-induced LRP1B and GPR6 proteins expressed early in Alzheimer disease mouse models, are essential for the C1q-mediated protection against amyloid-β neurotoxicity.
Gpr6 is the first striatopallidal neuron-specific genetic regulator of instrumental conditioning in a mammal.
Title: Genetic control of instrumental conditioning by striatopallidal neuron-specific S1P receptor Gpr6.
identification, characterization and cloning; identified sphingosine-1-phosphate as a high-affinity ligand
Title: Sphingosine-1-phosphate is a high-affinity ligand for the G protein-coupled receptor GPR6 from mouse and induces intracellular Ca2+ release by activating the sphingosine-kinase pathway.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

General gene information

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Markers

Gpr6 (e-PCR), detects polymorphism
- UniSTS:234031

D6S2092 (e-PCR)
- UniSTS:48444

UniSTS:495955 (e-PCR)
- UniSTS:495955

Gpr6 (e-PCR), detects polymorphism
- UniSTS:495955

AI852874 (e-PCR)
- UniSTS:164436

UniSTS:489566 (e-PCR)
- UniSTS:489566

Gpr6 (e-PCR), detects polymorphism
- UniSTS:463016

RH70579 (e-PCR)
- UniSTS:78267

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables sphingosine-1-phosphate receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphingosine-1-phosphate receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in sphingosine-1-phosphate receptor signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: G-protein coupled receptor 6

Names: sphingosine 1-phosphate receptor GPR6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199058.2 → NP_951013.1 G-protein coupled receptor 6

See identical proteins and their annotated locations for NP_951013.1

Status: VALIDATED

Source sequence(s)

AK139367, AW046789, CX236691

Consensus CDS

CCDS23802.1

UniProtKB/Swiss-Prot

Q6YNI2

UniProtKB/TrEMBL

Q2M2N8

Related

ENSMUSP00000057323.7, ENSMUST00000061796.8

Conserved Domains (2) summary

cd14964
Location:76 → 100

7tm_GPCRs; TM helix 1 [structural motif]

cl28897
Location:74 → 341

7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily