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    nsun-2 Doublecortin domain-containing protein;SAM-dependent MTase RsmB/NOP-type domain-containing protein;tRNA (cytosine(34)-C(5))-methyltransferase [ Caenorhabditis elegans ]

    Gene ID: 171697, updated on 4-Jan-2025

    Summary

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    Official Symbol
    nsun-2
    Official Full Name
    Doublecortin domain-containing protein;SAM-dependent MTase RsmB/NOP-type domain-containing protein;tRNA (cytosine(34)-C(5))-methyltransferase
    Primary source
    WormBase:WBGene00021686
    Locus tag
    CELE_Y48G8AL.5
    See related
    AllianceGenome:WB:WBGene00021686
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables tRNA (cytidine-5-)-methyltransferase activity. Predicted to be involved in tRNA methylation. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 5. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See nsun-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    7
    Sequence:
    Chromosome: I; NC_003279.8 (1193158..1211376)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Origin recognition complex subunit 6 Neighboring gene ABC transporter ATP-binding protein;ATP-binding cassette sub-family B member 8, mitochondrial Neighboring gene Regulator of nonsense transcripts 1 Neighboring gene ncRNA Neighboring gene FIP (Fungus-Induced Protein) Related;Fungus-induced protein 1 Neighboring gene HECT domain-containing protein Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The ribosomal RNA m(5)C methyltransferase NSUN-1 modulates healthspan and oogenesis in Caenorhabditis elegans. Heissenberger C, et al. Elife, 2020 Dec 8. PMID 33289480, Free PMC Article
    2. Translational adaptation to heat stress is mediated by RNA 5-methylcytosine in Caenorhabditis elegans. Navarro IC, et al. EMBO J, 2021 Mar 15. PMID 33283887, Free PMC Article
    3. Nucleotide modifications in messenger RNA and their role in development and disease. Dezi V, et al. Biochem Soc Trans, 2016 Oct 15. PMID 27911721
    4. Trifunctional cross-linker for mapping protein-protein interaction networks and comparing protein conformational states. Tan D, et al. Elife, 2016 Mar 8. PMID 26952210, Free PMC Article
    5. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (cytidine-5-)-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA (cytidine-5-)-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA (cytidine-5-)-methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA methylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Doublecortin domain-containing protein;SAM-dependent MTase RsmB/NOP-type domain-containing protein;tRNA (cytosine(34)-C(5))-methyltransferase
    NP_001293222.1
    • Confirmed by transcript evidence
    NP_001293223.1
    • Confirmed by transcript evidence
    NP_001293224.1
    • Confirmed by transcript evidence
    NP_490830.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      1193158..1211376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_058429.7 → NP_490830.3  tRNA (cytosine(34)-C(5))-methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_490830.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9BL15
      Conserved Domains (1) summary
      COG0144
      Location:1 → 420
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    2. NM_001306293.3 → NP_001293222.1  tRNA (cytosine(34)-C(5))-methyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293222.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLP2
      Conserved Domains (1) summary
      COG0144
      Location:2 → 220
      RsmB; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]

    3. NM_001306294.4 → NP_001293223.1  SAM-dependent MTase RsmB/NOP-type domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293223.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CLJ9

    4. NM_001306295.3 → NP_001293224.1  Doublecortin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001293224.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CJ77
    Nucleotide Protein
    Heading Accession and Version

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