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    selt-1.2 Thioredoxin reductase-like selenoprotein T homolog selt-1.2 [ Caenorhabditis elegans ]

    Gene ID: 185097, updated on 9-Dec-2024

    Summary

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    Official Symbol
    selt-1.2
    Official Full Name
    Thioredoxin reductase-like selenoprotein T homolog selt-1.2
    Primary source
    WormBase:WBGene00009238
    Locus tag
    CELE_F28H7.4
    See related
    AllianceGenome:WB:WBGene00009238
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable thioredoxin-disulfide reductase (NADPH) activity. Predicted to be involved in cell redox homeostasis. Predicted to be located in several cellular components, including axon; dendrite; and perikaryon. Predicted to be active in endoplasmic reticulum membrane. Is expressed in AWBL and AWBR. Orthologous to human SELENOT (selenoprotein T). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See selt-1.2 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (10746496..10747363, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene WD repeat-containing protein wdr-5.3 Neighboring gene Uncharacterized protein Neighboring gene Serpentine Receptor, class J Neighboring gene Serpentine Receptor, class J Neighboring gene DeHydrogenases, Short chain Neighboring gene Fungal lipase-like domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans. Romanelli-Cedrez L, et al. Free Radic Biol Med, 2017 Jul. PMID 28347729
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. this study shows that selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans
      Title: Selenoprotein T is required for pathogenic bacteria avoidance in Caenorhabditis elegans.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thioredoxin-disulfide reductase (NADPH) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell redox homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Thioredoxin reductase-like selenoprotein T homolog selt-1.2
    NP_505741.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      10746496..10747363 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073340.3 → NP_505741.2  Thioredoxin reductase-like selenoprotein T homolog selt-1.2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_505741.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19892
      Conserved Domains (1) summary
      cl01407
      Location:72 → 209
      Rdx; Rdx family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19892.2

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