Jagn1 jagunal homolog 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Jagn1provided by RGD
Official Full Name: jagunal homolog 1provided by RGD
Primary source: RGD:1565488
See related: EnsemblRapid:ENSRNOG00000009175 AllianceGenome:RGD:1565488
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in severe congenital neutropenia 6. Orthologous to human JAGN1 (jagunal homolog 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Kidney (RPKM 155.9), Liver (RPKM 130.9) and 9 other tissues See more
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 4q42

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (148147213..148151915)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (146591577..146596287)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (145399885..145404605)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results identify a novel role for Jagn1 in regulating proinsulin biosynthesis.
Title: Jagn1 Is Induced in Response to ER Stress and Regulates Proinsulin Biosynthesis.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in defense response to fungus	ISO Inferred from Sequence Orthology more info
involved_in defense response to fungus	ISS Inferred from Sequence or Structural Similarity more info
involved_in endoplasmic reticulum organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in endoplasmic reticulum organization	IEA Inferred from Electronic Annotation more info
involved_in granulocyte colony-stimulating factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in granulocyte colony-stimulating factor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in granulocyte colony-stimulating factor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in neutrophil differentiation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil differentiation	ISO Inferred from Sequence Orthology more info
involved_in neutrophil differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil mediated immunity	ISO Inferred from Sequence Orthology more info
involved_in neutrophil mediated immunity	ISS Inferred from Sequence or Structural Similarity more info
involved_in neutrophil migration	ISO Inferred from Sequence Orthology more info
involved_in neutrophil migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in vesicle-mediated transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: protein jagunal homolog 1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044272.1 → NP_001037737.1 protein jagunal homolog 1

See identical proteins and their annotated locations for NP_001037737.1

Status: PROVISIONAL

Source sequence(s)

BC098749

UniProtKB/Swiss-Prot

Q4KM64

UniProtKB/TrEMBL

A0A8I5ZXA3, A6IBS0

Related

ENSRNOP00000053385.2, ENSRNOT00000012177.7

Conserved Domains (1) summary

pfam07086
Location:1 → 177

Jagunal; ER re-organisation during oogenesis

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

148147213..148151915

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006237053.5 → XP_006237115.1 protein jagunal homolog 1 isoform X2

Conserved Domains (1) summary

pfam07086
Location:1 → 29

Jagunal; Jagunal, ER re-organization during oogenesis
XM_063286616.1 → XP_063142686.1 protein jagunal homolog 1 isoform X1