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    Psmc3ip PSMC3 interacting protein [ Rattus norvegicus (Norway rat) ]

    Gene ID: 140938, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Psmc3ipprovided by RGD
    Official Full Name
    PSMC3 interacting proteinprovided by RGD
    Primary source
    RGD:621885
    See related
    EnsemblRapid:ENSRNOG00000020022 AllianceGenome:RGD:621885
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gt198; Tbpip
    Summary
    Enables DNA binding domain binding activity; nuclear receptor binding activity; and nuclear receptor coactivator activity. Involved in positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Predicted to be part of DNA recombinase auxiliary factor complex. Predicted to be active in condensed nuclear chromosome. Human ortholog(s) of this gene implicated in ovarian dysgenesis 3. Orthologous to human PSMC3IP (PSMC3 interacting protein). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 105.9), Thymus (RPKM 38.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Psmc3ip in Genome Data Viewer
    Location:
    10q31
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (86524546..86527764, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (86024281..86027928, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (89002109..89006075, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene hydroxysteroid (17-beta) dehydrogenase 1 Neighboring gene Coenzyme A synthase Neighboring gene MAX dimerization protein MLX Neighboring gene uncharacterized LOC134480875 Neighboring gene reticulophagy regulator family member 3 Neighboring gene tubulin, gamma 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. XX ovarian dysgenesis is caused by a PSMC3IP/HOP2 mutation that abolishes coactivation of estrogen-driven transcription. Zangen D, et al. Am J Hum Genet, 2011 Oct 7. PMID 21963259, Free PMC Article
    2. Identification and characterization of a tissue-specific coactivator, GT198, that interacts with the DNA-binding domains of nuclear receptors. Ko L, et al. Mol Cell Biol, 2002 Jan. PMID 11739747, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding domain binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear androgen receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear estrogen receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear glucocorticoid receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nuclear receptor coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear receptor coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear thyroid hormone receptor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-containing complex binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables recombinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in homologous chromosome pairing at meiosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in meiotic joint molecule formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic strand invasion involved in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein-containing complex assembly TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in reciprocal meiotic recombination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reciprocal meiotic recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA recombinase auxiliary factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    homologous-pairing protein 2 homolog
    Names
    nuclear receptor coactivator GT198
    proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein
    proteasome 26S ATPase subunit 3-interacting protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_134458.2 → NP_604453.2  homologous-pairing protein 2 homolog

      Status: VALIDATED

      Source sequence(s)
      AF352812, CK840952
      UniProtKB/Swiss-Prot
      Q91ZY6
      UniProtKB/TrEMBL
      A6HJ83, G3V8N3
      Related
      ENSRNOP00000027159.4, ENSRNOT00000027159.8
      Conserved Domains (2) summary
      pfam07106
      Location:12 → 74
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
      pfam18517
      Location:154 → 210
      LZ3wCH; Leucine zipper with capping helix domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      86524546..86527764 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006247249.5 → XP_006247311.1  homologous-pairing protein 2 homolog isoform X1

      UniProtKB/TrEMBL
      A6HJ83, G3V8N3
      Conserved Domains (1) summary
      pfam07106
      Location:16 → 179
      TBPIP; Tat binding protein 1(TBP-1)-interacting protein (TBPIP)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91ZY6.1 GenPept UniProtKB/Swiss-Prot:Q91ZY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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