SLY1 F-box family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: SLY1
Official Full Name: F-box family protein
Primary source: TAIR:AT4G24210
Locus tag: AT4G24210
See related: Araport:AT4G24210
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: SLEEPY1; T22A6.40; T22A6_40
Summary: F-box protein that is involved in GA signaling. Regulates seed germination. Component of E3 ubiquitin complex. Interacts with DELLA proteins.
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Genomic context

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See SLY1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 1

Sequence:: Chromosome: 4; NC_003075.7 (12563279..12564482)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis retromer subunit AtVPS29 is involved in SLY1-mediated gibberellin signaling.
Title: Arabidopsis retromer subunit AtVPS29 is involved in SLY1-mediated gibberellin signaling.
results indicate that, in Arabidopsis, AtSIZ1 positively controls GA signalling through SLY1 sumoylation.
Title: E3 SUMO ligase AtSIZ1 positively regulates SLY1-mediated GA signalling and plant development.
The stronger role of GID1b in non-proteolytic gibberellic acid signaling may result from the fact that GID1b has higher affinity for DELLA protein than GID1a and GID1c.
Title: The roles of the GA receptors GID1a, GID1b, and GID1c in sly1-independent GA signaling.
SNE function partly overlaps with SLY1 function in gibberellin signaling.
Title: The role of two f-box proteins, SLEEPY1 and SNEEZY, in Arabidopsis gibberellin signaling.
DELLA degradation causing GA responses requires GA biosynthesis, three functionally redundant GA receptors GIBBERELLIN INSENSITIVE DWARF1 (GID1a, b, and c), and the SLEEPY1 (SLY1) F-box subunit of an SCF E3 ubiquitin ligase.
Title: Proteolysis-independent downregulation of DELLA repression in Arabidopsis by the gibberellin receptor GIBBERELLIN INSENSITIVE DWARF1.
RGL2 disappearance is not a prerequisite for seed germination in the sly1 background.
Title: Seed germination of GA-insensitive sleepy1 mutants does not require RGL2 protein disappearance in Arabidopsis.
SLY1 interacts directly with RGA and GA INSENSITIVE (GAI, a closely related DELLA protein) via their C-terminal GRAS domain
Title: The Arabidopsis F-box protein SLEEPY1 targets gibberellin signaling repressors for gibberellin-induced degradation.
SLY1 (the wild-type form) and sly1gar2-1 both confer substrate specificity on this complex via specific binding to the DELLA proteins
Title: The Arabidopsis mutant sleepy1gar2-1 protein promotes plant growth by increasing the affinity of the SCFSLY1 E3 ubiquitin ligase for DELLA protein substrates.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_118554.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of gibberellic acid mediated signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of gibberellic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of gibberellic acid mediated signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within response to gibberellin	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within seed dormancy process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seed germination	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within seed germination	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: F-box family protein

NP_194152.1

SLEEPY1 (SLY1); CONTAINS InterPro DOMAIN/s: F-box domain, cyclin-like (InterPro:IPR001810), F-box domain, Skp2-like (InterPro:IPR022364); BEST Arabidopsis thaliana protein match is: F-box family protein (TAIR:AT5G48170.1); Has 122 Blast hits to 122 proteins in 25 species: Archae - 0; Bacteria - 2; Metazoa - 2; Fungi - 9; Plants - 109; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).