U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    GTR1 Major facilitator superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823951, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    GTR1
    Official Full Name
    Major facilitator superfamily protein
    Primary source
    TAIR:AT3G47960
    Locus tag
    AT3G47960
    See related
    Araport:AT3G47960
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtNPF2.10; GLUCOSINOLATE TRANSPORTER-1; NPF2.10; NRT1/ PTR family 2.10
    Summary
    Encodes a high-affinity, proton-dependent glucosinolate-specific transporter that is crucial for the transport of both methionine- and tryptophan-derived glucosinolates to seeds.
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See GTR1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    4
    Sequence:
    Chromosome: 3; NC_003074.8 (17697942..17700923, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene L-galactono-1,4-lactone dehydrogenase Neighboring gene DNAJ heat shock family protein Neighboring gene H[+]-ATPase 4 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Glucosinolate Transporter1 involves in salt-induced jasmonate signaling and alleviates the repression of lateral root growth by salt in Arabidopsis. Kuo HY, et al. Plant Sci, 2020 Aug. PMID 32563451
    2. Dimerization of GTR1 regulates their plasma membrane localization. Ishimaru Y, et al. Plant Signal Behav, 2017 Jun 3. PMID 28594299, Free PMC Article
    3. GTR1 is a jasmonic acid and jasmonoyl-l-isoleucine transporter in Arabidopsis thaliana. Ishimaru Y, et al. Biosci Biotechnol Biochem, 2017 Feb. PMID 27760496
    4. Phosphorylation at serine 52 and 635 does not alter the transport properties of glucosinolate transporter AtGTR1. Jørgensen ME, et al. Plant Signal Behav, 2016. PMID 26340317, Free PMC Article
    5. Elucidating the role of transport processes in leaf glucosinolate distribution. Madsen SR, et al. Plant Physiol, 2014 Nov. PMID 25209984, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Glucosinolate Transporter1 involves in salt-induced jasmonate signaling and alleviates the repression of lateral root growth by salt in Arabidopsis.
      Title: Glucosinolate Transporter1 involves in salt-induced jasmonate signaling and alleviates the repression of lateral root growth by salt in Arabidopsis.
    2. Expression of glucosinolate (GLS) importers GTR1 and GTR2 inside the stele, along with earlier observations, suggest three possible routes of stele-synthesized aliphatic GLS after their synthesis: (i) GTR-dependent import to cells symplastically connected to cortical cells and rhizosphere; (ii) GTR-independent transport via xylem to the shoot; and (iii) GTR-dependent import to GLS-degrading myrosin cells at the cortex.
      Title: Rhizosecretion of stele-synthesized glucosinolates and their catabolites requires GTR-mediated import in Arabidopsis.
    3. dimerization of GTR1, possibly induced by dephosphorylation of the Thr residue located between the possible transmembrane regions, regulates its plasma membrane localization.
      Title: Dimerization of GTR1 regulates their plasma membrane localization.
    4. GTR1 would be involved in the translocation of JA and JA-Ile in plant and may be contributed to correct positioning of JA and JA-Ile to attenuate an excessive wound response in undamaged leaves
      Title: GTR1 is a jasmonic acid and jasmonoyl-l-isoleucine transporter in Arabidopsis thaliana.
    5. Phosphorylation of AtGTR1 is not directly involved in regulating AtGTR1 transport activity.
      Title: Phosphorylation at serine 52 and 635 does not alter the transport properties of glucosinolate transporter AtGTR1.
    6. GTR1 role of transport processes in leaf glucosinolate distribution
      Title: Elucidating the role of transport processes in leaf glucosinolate distribution.
    7. glucosinolate can specifically translocate from rosette and roots to inflorescence in a GTR1- and GTR2-dependent manner
      Title: Upon bolting the GTR1 and GTR2 transporters mediate transport of glucosinolates to the inflorescence rather than roots.
    8. GTR1 and GTR2 control the loading of glucosinolates from the apoplasm into the phloem. [GTR1]
      Title: NRT/PTR transporters are essential for translocation of glucosinolate defence compounds to seeds.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    NM_114665.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glucosinolate:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within glucosinolate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucosinolate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phloem glucosinolate loading IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in Golgi trans cisterna HDA PubMed 
    located_in cytosol HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Major facilitator superfamily protein
    NP_566896.2
    • Major facilitator superfamily protein; FUNCTIONS IN: transporter activity; INVOLVED IN: oligopeptide transport; LOCATED IN: plasma membrane, membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Oligopeptide transporter (InterPro:IPR000109), Major facilitator superfamily, general substrate transporter (InterPro:IPR016196); BEST Arabidopsis thaliana protein match is: Major facilitator superfamily protein (TAIR:AT5G62680.1); Has 3941 Blast hits to 3750 proteins in 534 species: Archae - 0; Bacteria - 697; Metazoa - 584; Fungi - 378; Plants - 2186; Viruses - 0; Other Eukaryotes - 96 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      17697942..17700923 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_114665.4 → NP_566896.2  Major facilitator superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566896.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q944G5, Q94K82, Q9SU59
      UniProtKB/TrEMBL
      A0A178V6P7, A0A5S9XKH1, A0A7G2EUT7
      Conserved Domains (1) summary
      cd17416
      Location:68 → 605
      MFS_NPF1_2; NRT1/PTR family (NPF), subfamily 1 and 2 of the Major Facilitator Superfamily of transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q944G5.3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools