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    gabbr1a gamma-aminobutyric acid (GABA) B receptor, 1a [ Danio rerio (zebrafish) ]

    Gene ID: 373873, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gabbr1aprovided by ZNC
    Official Full Name
    gamma-aminobutyric acid (GABA) B receptor, 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030904-5
    See related
    Ensembl:ENSDARG00000018967 AllianceGenome:ZFIN:ZDB-GENE-030904-5
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    gabbr1
    Summary
    Predicted to enable G protein-coupled GABA receptor activity. Predicted to be involved in gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be part of G protein-coupled receptor heterodimeric complex. Is expressed in female organism; male organism; and nervous system. Human ortholog(s) of this gene implicated in alcohol dependence; amphetamine abuse; cocaine dependence; heroin dependence; and nicotine dependence. Orthologous to human GABBR1 (gamma-aminobutyric acid type B receptor subunit 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See gabbr1a in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (34716067..34845339, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (34858513..34987677, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene lymphotoxin alpha (TNF superfamily, member 1) Neighboring gene tumor necrosis factor b (TNF superfamily, member 2) Neighboring gene SH3-binding domain protein 5-like, a Neighboring gene alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Trans-inhibition of axon terminals underlies competition in the habenulo-interpeduncular pathway. Zaupa M, et al. Curr Biol, 2021 Nov 8. PMID 34529937, Free PMC Article
    2. Npas4a expression in the teleost forebrain is associated with stress coping style differences in fear learning. Baker MR, et al. Sci Rep, 2021 Jun 8. PMID 34103598, Free PMC Article
    3. Immunohistochemical localization of GABA, GAD65, and the receptor subunits GABAAalpha1 and GABAB1 in the zebrafish cerebellum. Delgado L, et al. Cerebellum, 2008. PMID 18633686
    4. Maintenance of Melanocyte Stem Cell Quiescence by GABA-A Signaling in Larval Zebrafish. Allen JR, et al. Genetics, 2019 Oct. PMID 31444245, Free PMC Article
    5. Multiplexed Genome Editing for Efficient Phenotypic Screening in Zebrafish. Guo S, et al. Vet Sci, 2022 Feb 19. PMID 35202345, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables G protein-coupled GABA receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    gamma-aminobutyric acid type B receptor subunit 1
    Names
    gaba1
    gamma-aminobutyric acid (GABA) B receptor, 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      34716067..34845339 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_689405.9 → XP_694497.5  gamma-aminobutyric acid type B receptor subunit 1

      UniProtKB/TrEMBL
      A0A8N7UVF8
      Related
      ENSDARP00000004577.7, ENSDART00000009892.8
      Conserved Domains (5) summary
      cd06366
      Location:168 → 561
      PBP1_GABAb_receptor; Ligand-binding domain of GABAb receptors, which are metabotropic transmembrane receptors for gamma-aminobutyric acid (GABA)
      smart00032
      Location:98 → 155
      CCP; Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR)
      pfam00003
      Location:601 → 855
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:184 → 541
      ANF_receptor; Receptor family ligand binding region
      pfam10211
      Location:883 → 925
      Ax_dynein_light; Axonemal dynein light chain
    Nucleotide Protein
    Heading Accession and Version

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