uts2a urotensin 2, alpha [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: uts2aprovided by ZNC
Official Full Name: urotensin 2, alphaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040630-11
See related: Ensembl:ENSDARG00000053854 AllianceGenome:ZFIN:ZDB-GENE-040630-11
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: UII-a
Summary: Predicted to enable hormone activity. Predicted to act upstream of or within blood vessel diameter maintenance and regulation of blood pressure. Predicted to be located in extracellular region. Is expressed in spinal cord. Human ortholog(s) of this gene implicated in gestational diabetes; hypertension; and type 2 diabetes mellitus. Orthologous to human UTS2 (urotensin 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (30048854..30055719)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (30122323..30129188)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results describe the distribution of urotensin I, UIIalpha and UIIbeta mRNAs in different organs and the cellular localization of the three mRNAs in the spinal cord by in situ hybridization (ISH) histochemistry.
Title: Comparative distribution of the mRNAs encoding urotensin I and urotensin II in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of blood pressure	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: urotensin 2, alpha

Names: urotensin II alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212848.3 → NP_998013.2 urotensin 2, alpha precursor

Status: VALIDATED

Source sequence(s)

BX663608

UniProtKB/TrEMBL

A0A8M1PIE4, F1QEG0

Related

ENSDARP00000111968.2, ENSDART00000126027.4

Conserved Domains (1) summary

pfam02083
Location:114 → 125

Urotensin_II; Urotensin II