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    cradd CASP2 and RIPK1 domain containing adaptor with death domain [ Danio rerio (zebrafish) ]

    Gene ID: 450046, updated on 9-Dec-2024

    Summary

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    Official Symbol
    craddprovided by ZNC
    Official Full Name
    CASP2 and RIPK1 domain containing adaptor with death domainprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041010-168
    See related
    Ensembl:ENSDARG00000028192 AllianceGenome:ZFIN:ZDB-GENE-041010-168
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:101717
    Summary
    Predicted to enable death domain binding activity and protease binding activity. Predicted to act upstream of or within regulation of apoptotic process and signal transduction. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 34. Orthologous to human CRADD (CASP2 and RIPK1 domain containing adaptor with death domain). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See cradd in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (18383080..18416759, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (18394104..18427783, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene plexin-C1-like Neighboring gene uncharacterized LOC108183547 Neighboring gene non-SMC condensin II complex, subunit H2 Neighboring gene suppressor of cytokine signaling 2 Neighboring gene synthesis of cytochrome C oxidase 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue factor pathway inhibitor-2: a novel gene involved in zebrafish central nervous system development. Zhang Y, et al. Dev Biol, 2013 Sep 1. PMID 23796905
    2. Evolution of JAK-STAT pathway components: mechanisms and role in immune system development. Liongue C, et al. PLoS One, 2012. PMID 22412924, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables death domain binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protease binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    death domain-containing protein CRADD

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006066.1 → NP_001006066.1  death domain-containing protein CRADD

      See identical proteins and their annotated locations for NP_001006066.1

      Status: PROVISIONAL

      Source sequence(s)
      BC083256
      UniProtKB/TrEMBL
      B2GRV1, Q5RGW2, Q5XJP2
      Related
      ENSDARP00000038654.5, ENSDART00000033717.6
      Conserved Domains (2) summary
      cd08319
      Location:117 → 199
      Death_RAIDD; Death domain of RIP-associated ICH-1 homologous protein with a death domain
      cd08327
      Location:1 → 91
      CARD_RAIDD; Caspase activation and recruitment domain of RIP-associated ICH-1 homologous protein with a death domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      18383080..18416759 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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