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    gja3 gap junction protein, alpha 3 [ Danio rerio (zebrafish) ]

    Gene ID: 387533, updated on 9-Dec-2024

    Summary

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    Official Symbol
    gja3provided by ZNC
    Official Full Name
    gap junction protein, alpha 3provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031217-3
    See related
    Ensembl:ENSDARG00000021889 AllianceGenome:ZFIN:ZDB-GENE-031217-3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    Cx44; cx46; cx48.5
    Summary
    Enables gap junction hemi-channel activity. Acts upstream of or within several processes, including cardiac muscle tissue development; cell communication by electrical coupling; and post-embryonic eye morphogenesis. Predicted to be located in plasma membrane. Predicted to be part of connexin complex. Is expressed in several structures, including kidney; liver; pericardial region; retina; and spinal cord. Human ortholog(s) of this gene implicated in cataract 14 multiple types. Orthologous to human GJA3 (gap junction protein alpha 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See gja3 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 9 NC_007120.7 (21405634..21411409)
    105 previous assembly GRCz10 (GCF_000002035.5) 9 NC_007120.6 (21594771..21600540)

    Chromosome 9 - NC_007120.7Genomic Context describing neighboring genes Neighboring gene crystallin, lambda 1 Neighboring gene gap junction protein beta 8 Neighboring gene uncharacterized LOC137490349 Neighboring gene zinc finger, MYM-type 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning, expression analysis, and functional characterization of connexin44.1: a zebrafish lens gap junction protein. Cason N, et al. Dev Dyn, 2001 Jun. PMID 11376491
    2. Cx46 hemichannel modulation by nitric oxide: Role of the fourth transmembrane helix cysteine and its possible involvement in cataract formation. Retamal MA, et al. Nitric Oxide, 2019 May 1. PMID 30797972
    3. Zebrafish cx30.3: identification and characterization of a gap junction gene highly expressed in the skin. Tao L, et al. Dev Dyn, 2010 Oct. PMID 20737512, Free PMC Article
    4. Connexin 48.5 is required for normal cardiovascular function and lens development in zebrafish embryos. Cheng S, et al. J Biol Chem, 2004 Aug 27. PMID 15213236
    5. Analysis of Cx43alpha1 promoter function in the developing zebrafish embryo. Chatterjee B, et al. Cell Commun Adhes, 2001. PMID 12064604

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cx48.5, Cx44.1, Cx43 have roles in lens development
      Title: Expression of connexin48.5, connexin44.1, and connexin43 during zebrafish (Danio rerio) lens development.
    2. Connexin 48.5 has a role in normal cardiovascular function and lens development in zebrafish embryos
      Title: Connexin 48.5 is required for normal cardiovascular function and lens development in zebrafish embryos.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables gap junction channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables gap junction hemi-channel activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cardiac conduction system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cardiac muscle tissue morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell communication IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell communication by electrical coupling IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell-cell signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within post-embryonic eye morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of heart contraction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of connexin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of connexin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in gap junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    gap junction alpha-3 protein
    Names
    connexin 48.5
    dco
    dococ
    gap junction membrane channel protein alpha 3
    unm s215
    unm s226

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_207642.1 → NP_997525.1  gap junction alpha-3 protein

      See identical proteins and their annotated locations for NP_997525.1

      Status: PROVISIONAL

      Source sequence(s)
      AF465751
      UniProtKB/TrEMBL
      B3DK92, Q8JFD2
      Related
      ENSDARP00000117213.1, ENSDART00000145627.2
      Conserved Domains (2) summary
      pfam00029
      Location:3 → 244
      Connexin; Connexin
      pfam16791
      Location:277 → 434
      Connexin40_C; Connexin 40 C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007120.7 Reference GRCz11 Primary Assembly

      Range
      21405634..21411409
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068223342.1 → XP_068079443.1  gap junction alpha-3 protein isoform X1

      UniProtKB/TrEMBL
      B3DK92, Q8JFD2

    2. XM_005167541.4 → XP_005167598.1  gap junction alpha-3 protein isoform X1

      See identical proteins and their annotated locations for XP_005167598.1

      UniProtKB/TrEMBL
      B3DK92, Q8JFD2
      Conserved Domains (2) summary
      pfam00029
      Location:3 → 244
      Connexin; Connexin
      pfam16791
      Location:277 → 434
      Connexin40_C; Connexin 40 C-terminal domain

    3. XM_068223343.1 → XP_068079444.1  gap junction alpha-3 protein isoform X1

      UniProtKB/TrEMBL
      B3DK92, Q8JFD2

    4. XM_021478628.2 → XP_021334303.1  gap junction alpha-3 protein isoform X1

      UniProtKB/TrEMBL
      B3DK92, Q8JFD2
      Conserved Domains (2) summary
      pfam00029
      Location:3 → 244
      Connexin; Connexin
      pfam16791
      Location:277 → 434
      Connexin40_C; Connexin 40 C-terminal domain

    5. XM_005167542.4 → XP_005167599.1  gap junction alpha-3 protein isoform X1

      See identical proteins and their annotated locations for XP_005167599.1

      UniProtKB/TrEMBL
      B3DK92, Q8JFD2
      Conserved Domains (2) summary
      pfam00029
      Location:3 → 244
      Connexin; Connexin
      pfam16791
      Location:277 → 434
      Connexin40_C; Connexin 40 C-terminal domain

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394749.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      273679..274983
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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