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    exosc4 exosome component 4 [ Danio rerio (zebrafish) ]

    Gene ID: 393712, updated on 9-Dec-2024

    Summary

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    Official Symbol
    exosc4provided by ZNC
    Official Full Name
    exosome component 4provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-1702
    See related
    Ensembl:ENSDARG00000103432 AllianceGenome:ZFIN:ZDB-GENE-040426-1702
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:73175
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in RNA metabolic process. Predicted to be located in cytoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Predicted to be active in nucleolus. Is expressed in several structures, including alar plate midbrain region; immature eye; midbrain; pectoral fin bud; and segmental plate. Orthologous to human EXOSC4 (exosome component 4). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See exosc4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (1939394..1943936)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (1596588..1601130)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene adhesion G protein-coupled receptor L2b, tandem duplicate 1 Neighboring gene adhesion G protein-coupled receptor L2-like Neighboring gene uncharacterized LOC137487357 Neighboring gene BCL10 immune signaling adaptor Neighboring gene mucolipin TRP cation channel 3a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Zebrafish Ski7 tunes RNA levels during the oocyte-to-embryo transition. Cabrera-Quio LE, et al. PLoS Genet, 2021 Feb. PMID 33600438, Free PMC Article
    2. Global repression of cancer gene expression in a zebrafish model of melanoma is linked to epigenetic regulation. Anelli V, et al. Zebrafish, 2009 Dec. PMID 20047469
    3. Spatio-temporal regulation of Wnt and retinoic acid signaling by tbx16/spadetail during zebrafish mesoderm differentiation. Mueller RL, et al. BMC Genomics, 2010 Sep 9. PMID 20828405, Free PMC Article
    4. Identification of 315 genes essential for early zebrafish development. Amsterdam A, et al. Proc Natl Acad Sci U S A, 2004 Aug 31. PMID 15256591, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC73175

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in U4 snRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear mRNA surveillance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in poly(A)-dependent snoRNA 3'-end processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in rRNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cytoplasmic exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of exosome (RNase complex) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of nuclear exosome (RNase complex) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    exosome complex component RRP41
    Names
    exosome complex exonuclease RRP41

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_200739.3 → NP_957033.1  exosome complex component RRP41

      See identical proteins and their annotated locations for NP_957033.1

      Status: VALIDATED

      Source sequence(s)
      FO704880, FP245444
      UniProtKB/TrEMBL
      Q6PBZ8
      Related
      ENSDARP00000138743.1, ENSDART00000163310.2
      Conserved Domains (2) summary
      cd11370
      Location:11 → 237
      RNase_PH_RRP41; RRP41 subunit of eukaryotic exosome
      PRK03983
      Location:1 → 227
      PRK03983; exosome complex exonuclease Rrp41; Provisional

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      1939394..1943936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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