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    c7b complement component 7b [ Danio rerio (zebrafish) ]

    Gene ID: 570832, updated on 9-Dec-2024

    Summary

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    Official Symbol
    c7bprovided by ZNC
    Official Full Name
    complement component 7bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-021120-1
    See related
    Ensembl:ENSDARG00000057121 AllianceGenome:ZFIN:ZDB-GENE-021120-1
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    c7; cb349; wu:fa01f03; si:dkey-246j23.5
    Summary
    Predicted to be involved in complement activation. Predicted to act upstream of or within complement activation, classical pathway; innate immune response; and killing of cells of another organism. Predicted to be located in extracellular region. Predicted to be part of membrane attack complex. Predicted to be active in extracellular space. Is expressed in central nervous system and yolk syncytial layer. Human ortholog(s) of this gene implicated in complement component 7 deficiency. Orthologous to human C7 (complement C7). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See c7b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (20901280..20915291)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (20864654..20878711)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene complement component 6, duplicate 1 Neighboring gene succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial-like Neighboring gene complement component 6, duplicate 2 Neighboring gene regulator of G protein signaling 7 binding protein b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression of complement component C7 and involvement in innate immune responses to bacteria in grass carp. Shen Y, et al. Fish Shellfish Immunol, 2012 Aug. PMID 22617254
    2. Identification and functional analysis of the perforin-1 like gene in disease resistance in half smooth tongue sole (Cynoglossus semilaevis). Fu X, et al. Dev Comp Immunol, 2021 Sep. PMID 34004267
    3. Rapid, Dynamic Activation of Müller Glial Stem Cell Responses in Zebrafish. Sifuentes CJ, et al. Invest Ophthalmol Vis Sci, 2016 Oct 1. PMID 27699411, Free PMC Article
    4. Metabolism disruption analysis of zebrafish larvae in response to BPA and BPA analogs based on RNA-Seq technique. Qiu W, et al. Ecotoxicol Environ Saf, 2019 Jun 15. PMID 30826544
    5. Neuroinflammatory signals drive spinal curve formation in zebrafish models of idiopathic scoliosis. Van Gennip JLM, et al. Sci Adv, 2018 Dec. PMID 30547092, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    involved_in complement activation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within complement activation, classical pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within killing of cells of another organism IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of membrane attack complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of membrane attack complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    complement component 7b
    Names
    C7-1
    complement component 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001386266.1 → NP_001373195.1  complement component 7b precursor

      Status: VALIDATED

      Source sequence(s)
      BX511186
      UniProtKB/TrEMBL
      A0A8M9PWA7, F1QF24, F1QKJ3
      Related
      ENSDARP00000114284.1, ENSDART00000132741.2
      Conserved Domains (6) summary
      PHA02639
      Location:563 → 689
      PHA02639; EEV host range protein; Provisional
      smart00209
      Location:40 → 90
      TSP1; Thrombospondin type 1 repeats
      cd00112
      Location:96 → 128
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      pfam01823
      Location:227 → 443
      MACPF; MAC/Perforin domain
      pfam18434
      Location:783 → 831
      Kazal_3; Kazal-type serine protease inhibitor domain
      cl20168
      Location:697 → 757
      Kazal_3; Kazal-type serine protease inhibitor domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      20901280..20915291
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018395089.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      76565..90576
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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    Research Materials