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    reps1 RALBP1 associated Eps domain containing 1 [ Danio rerio (zebrafish) ]

    Gene ID: 564535, updated on 27-Dec-2024

    Summary

    Official Symbol
    reps1provided by ZNC
    Official Full Name
    RALBP1 associated Eps domain containing 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-9536
    See related
    Ensembl:ENSDARG00000002877 AllianceGenome:ZFIN:ZDB-GENE-030131-9536
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wu:fj85c06; si:dkey-217m5.1
    Summary
    Predicted to enable calcium ion binding activity. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation. Orthologous to human REPS1 (RALBP1 associated Eps domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See reps1 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (39222814..39258515)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (39319585..39355633)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene regulator of calcineurin 2 Neighboring gene uncharacterized LOC108180313 Neighboring gene cytochrome P450, family 39, subfamily A, polypeptide 1 Neighboring gene clusterin Neighboring gene scavenger receptor class A, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Pathways from PubChem

    General protein information

    Preferred Names
    ralBP1-associated Eps domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045056.2NP_001038521.1  ralBP1-associated Eps domain-containing protein 1

      Status: PROVISIONAL

      Source sequence(s)
      AL845306, AL929058
      UniProtKB/TrEMBL
      A0A8M1N9W4, Q5VSI7
      Related
      ENSDARP00000117870.1, ENSDART00000132132.4
      Conserved Domains (3) summary
      smart00027
      Location:275366
      EH; Eps15 homology domain
      cd00052
      Location:286352
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cl08302
      Location:1481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      39222814..39258515
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005160831.5XP_005160888.1  ralBP1-associated Eps domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B7S1
      Conserved Domains (3) summary
      smart00027
      Location:275366
      EH; Eps15 homology domain
      cd00052
      Location:286352
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cl08302
      Location:1481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    2. XM_005160832.5XP_005160889.1  ralBP1-associated Eps domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8M2B7T2
      Conserved Domains (3) summary
      smart00027
      Location:275366
      EH; Eps15 homology domain
      cd00052
      Location:286352
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cl08302
      Location:1481
      EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    3. XM_021468478.2XP_021324153.1  ralBP1-associated Eps domain-containing protein 1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9PBU8
      Conserved Domains (3) summary
      smart00027
      Location:275366
      EH; Eps15 homology domain
      cl25836
      Location:129260
      Retinal; Retinal protein
      cl27812
      Location:1085
      EF-hand_4; Cytoskeletal-regulatory complex EF hand