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    arhgef18a rho/rac guanine nucleotide exchange factor (GEF) 18a [ Danio rerio (zebrafish) ]

    Gene ID: 407987, updated on 9-Dec-2024

    Summary

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    Official Symbol
    arhgef18aprovided by ZNC
    Official Full Name
    rho/rac guanine nucleotide exchange factor (GEF) 18aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040516-14
    See related
    Ensembl:ENSDARG00000011157 AllianceGenome:ZFIN:ZDB-GENE-040516-14
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    arhgef18; zgc:85686; wu:fc21e04; wu:fj05f11
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of Rho protein signal transduction. Predicted to be located in cytoplasm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in retinitis pigmentosa. Orthologous to human ARHGEF18 (Rho/Rac guanine nucleotide exchange factor 18). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See arhgef18a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37504223..37537927, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37521633..37555508, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene death-associated protein kinase 3 Neighboring gene signal peptide peptidase-like 2 Neighboring gene insulin receptor a Neighboring gene major facilitator superfamily domain containing 14A2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article
    2. Hematopoietic gene expression profile in zebrafish kidney marrow. Song HD, et al. Proc Natl Acad Sci U S A, 2004 Nov 16. PMID 15520368, Free PMC Article
    3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    rho guanine nucleotide exchange factor 18a
    Names
    rho/rac guanine nucleotide exchange factor (GEF) 18

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_214818.1 → NP_999983.1  rho guanine nucleotide exchange factor 18a

      See identical proteins and their annotated locations for NP_999983.1

      Status: PROVISIONAL

      Source sequence(s)
      BC070002
      UniProtKB/TrEMBL
      Q6NSP2
      Related
      ENSDARP00000016874.7, ENSDART00000025841.9
      Conserved Domains (3) summary
      pfam00621
      Location:74 → 266
      RhoGEF; RhoGEF domain
      pfam13863
      Location:650 → 747
      DUF4200; Domain of unknown function (DUF4200)
      cl17171
      Location:307 → 427
      PH-like; Pleckstrin homology-like domain

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      37504223..37537927 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005171284.5 → XP_005171341.1  rho guanine nucleotide exchange factor 18a isoform X1

      See identical proteins and their annotated locations for XP_005171341.1

      UniProtKB/TrEMBL
      A0A8M3AXD6, F1REH9
      Conserved Domains (3) summary
      cd00160
      Location:71 → 265
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:307 → 420
      PH-like; Pleckstrin homology-like domain
      cl26472
      Location:597 → 726
      DUF3084; Protein of unknown function (DUF3084)

    2. XM_021479667.2 → XP_021335342.1  rho guanine nucleotide exchange factor 18a isoform X1

      UniProtKB/TrEMBL
      A0A8M3AXD6, F1REH9
      Conserved Domains (3) summary
      cd00160
      Location:71 → 265
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:307 → 420
      PH-like; Pleckstrin homology-like domain
      cl26472
      Location:597 → 726
      DUF3084; Protein of unknown function (DUF3084)

    3. XM_009298637.4 → XP_009296912.1  rho guanine nucleotide exchange factor 18a isoform X1

      See identical proteins and their annotated locations for XP_009296912.1

      UniProtKB/TrEMBL
      A0A8M3AXD6, F1REH9
      Conserved Domains (3) summary
      cd00160
      Location:71 → 265
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cl17171
      Location:307 → 420
      PH-like; Pleckstrin homology-like domain
      cl26472
      Location:597 → 726
      DUF3084; Protein of unknown function (DUF3084)
    Nucleotide Protein Strain
    Heading Accession and Version

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