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    celf3a cugbp, Elav-like family member 3a [ Danio rerio (zebrafish) ]

    Gene ID: 57922, updated on 9-Dec-2024

    Summary

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    Official Symbol
    celf3aprovided by ZNC
    Official Full Name
    cugbp, Elav-like family member 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-000501-2
    See related
    Ensembl:ENSDARG00000034668 AllianceGenome:ZFIN:ZDB-GENE-000501-2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    etr1; celf3; etr-1; tnrc4
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site recognition; positive regulation of mRNA splicing, via spliceosome; and regulation of alternative mRNA splicing, via spliceosome. Predicted to act upstream of or within mRNA processing. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Orthologous to human CELF3 (CUGBP Elav-like family member 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See celf3a in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 19 NC_007130.7 (8816657..8895396, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 19 NC_007130.6 (8897732..8961817, complement)

    Chromosome 19 - NC_007130.7Genomic Context describing neighboring genes Neighboring gene si:ch73-350k19.1 Neighboring gene ceramide synthase 2a Neighboring gene regulation of nuclear pre-mRNA domain containing 2a Neighboring gene circadian associated repressor of transcription a Neighboring gene mitochondrial ribosomal protein S21

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The effects of aliphatic alcohols and related acid metabolites in zebrafish embryos - correlations with rat developmental toxicity and with effects in advanced life stages in fish. van der Ven LTM, et al. Toxicol Appl Pharmacol, 2020 Nov 15. PMID 32979392
    2. Evolution of vertebrate nicotinic acetylcholine receptors. Pedersen JE, et al. BMC Evol Biol, 2019 Jan 30. PMID 30700248, Free PMC Article
    3. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CUGBP Elav-like family member 3
    Names
    CELF-3
    CUG-BP- and ETR-3-like factor 3
    ELAV-type RNA-binding protein 1
    RNA-binding protein BRUNOL-1
    bruno-like protein 1
    cugbp, Elav-like family member 3
    trinucleotide repeat containing 4
    trinucleotide repeat-containing gene 4 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131494.2 → NP_571569.2  CUGBP Elav-like family member 3

      See identical proteins and their annotated locations for NP_571569.2

      Status: PROVISIONAL

      Source sequence(s)
      BC060923
      UniProtKB/Swiss-Prot
      Q6P953, Q9IBD1
      Related
      ENSDARP00000039628.6, ENSDART00000039629.7
      Conserved Domains (5) summary
      cd12632
      Location:2 → 88
      RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:93 → 173
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12639
      Location:363 → 441
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:9 → 448
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      pfam05308
      Location:232 → 295
      Mito_fiss_reg; Mitochondrial fission regulator

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007130.7 Reference GRCz11 Primary Assembly

      Range
      8816657..8895396 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068215181.1 → XP_068071282.1  CUGBP Elav-like family member 3 isoform X2

      UniProtKB/Swiss-Prot
      Q6P953, Q9IBD1

    2. XM_068215179.1 → XP_068071280.1  CUGBP Elav-like family member 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PGK3

    3. XM_021468129.2 → XP_021323804.1  CUGBP Elav-like family member 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PGK3
      Conserved Domains (4) summary
      cd12632
      Location:2 → 88
      RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:93 → 173
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12639
      Location:369 → 447
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cl26464
      Location:225 → 348
      Atrophin-1; Atrophin-1 family

    4. XM_068215180.1 → XP_068071281.1  CUGBP Elav-like family member 3 isoform X1

      UniProtKB/TrEMBL
      A0A8M9PGK3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9IBD1.2 GenPept UniProtKB/Swiss-Prot:Q9IBD1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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