jag2b jagged canonical Notch ligand 2b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: jag2bprovided by ZNC
Official Full Name: jagged canonical Notch ligand 2bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-011128-3
See related: Ensembl:ENSDARG00000021389 AllianceGenome:ZFIN:ZDB-GENE-011128-3
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: jag2; serB; zgc:152855
Summary: Predicted to enable Notch binding activity and calcium ion binding activity. Acts upstream of or within several processes, including exocrine pancreas development; hematopoietic stem cell differentiation; and ventral spinal cord development. Predicted to be located in membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including anterior neural rod; digestive system; mesoderm; nervous system; and trunk. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy. Orthologous to human JAG2 (jagged canonical Notch ligand 2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (21391188..21475630)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (21491503..21575957)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Jagged 2b induces intercellular signaling within somites to establish hematopoietic stem cell fate in zebrafish.
Title: Jagged 2b induces intercellular signaling within somites to establish hematopoietic stem cell fate in zebrafish.
Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance.
Title: Multiple myeloma exploits Jagged1 and Jagged2 to promote intrinsic and bone marrow-dependent drug resistance.
Notch ligands Jagged1b and Jagged2b induce duct cell lineage in the liver and pancreas of the zebrafish.
Title: Endoderm Jagged induces liver and pancreas duct lineage in zebrafish.
Results indicate that Jagged-Notch signaling is required for segregation between wt1-expressing cells and differentiated steroidogenic tissue.
Title: Aberrant Global and Jagged-Mediated Notch Signaling Disrupts Segregation Between wt1-Expressing and Steroidogenic Tissues in Zebrafish.
Expression of both jagged2 and jagged1b mRNA in the central nervous system suggested that they might be involved in control of differentiating neural progenitors.
Title: Proliferating neural progenitors in the developing CNS of zebrafish require Jagged2 and Jagged1b.
Mice homozygous for a deletion in the Notch-interaction domain of Jag2 presented a variety of severe dental abnormalities.
Title: BMPs and FGFs target Notch signalling via jagged 2 to regulate tooth morphogenesis and cytodifferentiation.
Jag2-mediated Notch signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord.
Title: Jagged-mediated Notch signaling maintains proliferating neural progenitors and regulates cell diversity in the ventral spinal cord.
Jagged and Delta ligands are functionally redundant or required in specific combinations in many differentiation processes
Title: Expression analysis of jagged genes in zebrafish embryos.

Submit: New GeneRIF Correction

General gene information

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Markers

fc59b09.x1 (e-PCR)
- UniSTS:194135

fl24c12.x1 (e-PCR)
- UniSTS:202085

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables Notch binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within cell communication	IEA Inferred from Electronic Annotation more info
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within exocrine pancreas development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intrahepatic bile duct development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within liver development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within liver development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pancreas development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord motor neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventral spinal cord interneuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein jagged-2b

Names: jagged 2; jagged 2b; serrateB; unp1068

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131862.1 → NP_571937.1 protein jagged-2b precursor

See identical proteins and their annotated locations for NP_571937.1

Status: PROVISIONAL

Source sequence(s)

AF229449

UniProtKB/TrEMBL

Q90Y56

Related

ENSDARP00000010799.5, ENSDART00000024922.7

Conserved Domains (5) summary

smart00215
Location:873 → 944

VWC_out; von Willebrand factor (vWF) type C domain

cd00054
Location:377 → 413

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:756 → 786

EGF; EGF-like domain

pfam01414
Location:170 → 232

DSL; Delta serrate ligand

pfam07657
Location:28 → 101

MNNL; N terminus of Notch ligand

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

21391188..21475630

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005160485.5 → XP_005160542.1 protein jagged-2b isoform X1

UniProtKB/TrEMBL

A0A8M2B7B8, Q5TZK7

Related

ENSDARP00000049585.5, ENSDART00000049586.6

Conserved Domains (5) summary

smart00215
Location:835 → 906

VWC_out; von Willebrand factor (vWF) type C domain

cd00054
Location:377 → 413

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

pfam00008
Location:718 → 748

EGF; EGF-like domain

pfam01414
Location:170 → 232

DSL; Delta serrate ligand

pfam07657
Location:28 → 101

MNNL; N terminus of Notch ligand