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    cd74b CD74 molecule, major histocompatibility complex, class II invariant chain b [ Danio rerio (zebrafish) ]

    Gene ID: 30645, updated on 9-Dec-2024

    Summary

    Official Symbol
    cd74bprovided by ZNC
    Official Full Name
    CD74 molecule, major histocompatibility complex, class II invariant chain bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-990910-10
    See related
    Ensembl:ENSDARG00000036628 AllianceGenome:ZFIN:ZDB-GENE-990910-10
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cd74; iclp2; Iclp-2; zgc:123161
    Summary
    Predicted to enable MHC class II protein binding activity; cytokine receptor activity; and macrophage migration inhibitory factor binding activity. Acts upstream of or within inner ear development and neuromast development. Predicted to be located in extracellular region and membrane. Predicted to be active in cell surface and cytoplasm. Is expressed in inner ear and otic vesicle. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See cd74b in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (33459562..33463893)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (33424063..33429514)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1b Neighboring gene uncharacterized LOC137488835 Neighboring gene SLC35A4 upstream open reading frame protein-like Neighboring gene ribosomal protein S14 Neighboring gene clathrin interactor 1b

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Clone Names

    • MGC123161, MGC158500

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables MHC class II protein binding  
    enables MHC class II protein binding  
    enables cytokine receptor activity  
    enables macrophage migration inhibitory factor binding  
    enables macrophage migration inhibitory factor binding  
    Process Evidence Code Pubs
    involved_in T cell activation involved in immune response  
    involved_in antigen processing and presentation  
    acts_upstream_of_or_within antigen processing and presentation  
    acts_upstream_of_or_within immune response  
    acts_upstream_of_or_within inner ear development PubMed 
    acts_upstream_of_or_within intracellular protein transport  
    involved_in negative regulation of DNA damage response, signal transduction by p53 class mediator  
    involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  
    acts_upstream_of_or_within neuromast development PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade  
    involved_in positive regulation of cytokine-mediated signaling pathway  
    involved_in positive regulation of macrophage cytokine production  
    involved_in positive regulation of type 2 immune response  
    Component Evidence Code Pubs
    is_active_in cell surface  
    is_active_in cytoplasm  
    located_in extracellular region  
    located_in membrane  

    General protein information

    Preferred Names
    CD74 molecule, major histocompatibility complex, class II invariant chain b
    Names
    invariant chain-like protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_131372.2 → NP_571447.1  CD74 molecule, major histocompatibility complex, class II invariant chain b

      See identical proteins and their annotated locations for NP_571447.1

      Status: PROVISIONAL

      Source sequence(s)
      BC127569
      UniProtKB/TrEMBL
      A1L140, Q9PVD9
      Related
      ENSDARP00000053204.4, ENSDART00000053205.6
      Conserved Domains (2) summary
      cd00191
      Location:121 → 179
      TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
      pfam09307
      Location:10 → 100
      MHC2-interact; CLIP, MHC2 interacting

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      33459562..33463893
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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